Efficacy of Shexiang Tongxin Dripping Pills in the Treatment of Microvascular Angina Pectoris and Its Clinical Safety
Objective To investigate the efficacy and clinical safety of Shexiang Tongxin dripping pills in the treatment of microvascular angina pectoris.Methods From December 2021 to December 2022,a total of 100 patients with microvascular angina pectoris admitted to Zhangzhou Traditional Chinese Medicial Hospital were randomly divided into musk group (n=52) and western medicine group (n=48).The western medicine group was treated with β-blocker or ivabradine,and the Shexiang group was treated with Shexiang Tongxin dripping pills on the basis of the western medicine group.Left ventricular ejection fraction and treadmill exercise duration were compared between the two groups.Results After 12 weeks of treatment,the left ventricular ejection fraction (LVEF) of the musk group was (68.28±5.13)％,which was significantly higher than that of the western medicine group (57.29±4.21)％,and the differences were statistically significant (P<0.05).The duration of treadmill exercise in the musk group was (534.13±95.23) s,which was significantly higher than that in the western medicine group (471.25±85.13) s,and the differences were statistically significant (P<0.05).The duration of angina pectoris in the musk group was (2.27±0.10) min,which was significantly shorter than (4.24±0.30) min in the western medicine group,and the differences were statistically significant (P<0.05).The frequency of angina pectoris attack was (3.55±0.25) times,which was significantly lower than that (6.45±0.15) times in the western medicine group,and the differences were statistically significant (P<0.05).The number of LAD,LCX,and RCA blood flow frames in the musk group were (32.19±1.29)frames,(28.27±4.20) frames,and (27.24±2.15) frames,respectively,which were lower than those inthe Western medicine group (38.35±1.24) frames,(34.11±3.18) frames,and (33.24±2.29) frames,and the difference was statistically significant (P<0.05).The adverse reactions in both groups were mild and disappeared after symptomatic treatment.Conclusion The combination of Shexiang Tongxin dripping pills and western medicine in treating microvascular angina pectoris can effectively improve the degree of myocardial ischemia and increase the coronary microvascular blood flow,and has remarkable clinical efficacy and high safety.
万方数据
维普
