The Clinical Efficacy of Qingxuan Huoluo Jiangya Decoction in the Treatment of H-Type Hypertension With Phlegm Blood Stasis and Its Impact on Vascular Endothelial Function
Objective To explore the clinical efficacy of Qingxuan Huoluo Jiangya Decoction in the treatment of H-type hypertension with phlegm stasis syndrome and its impact on endothelial function.Methods A total of patients with H-type hypertension who visited the department of cardiovascular,Hospital of Traditional Chinese Medicine of Qiqihar from February 2023 to February 2024 were randomly divided into a treatment group and a control group,with 40 patients in each group.The control group only received treatment with enalapril maleate tablets once a day,10 mg/time,for 8 weeks.On this basis,the treatment group added Qingxuan Huoluo Jiangya Tang,1 dose/day,taken half an hour after breakfast and dinner,for 8 weeks.Research observation indicators include blood pressure,endothelial injury indicators,carotid intima-media thickness (IMT),serum homocysteine (Hcy) levels,plasma soluble intercellular adhesion molecule-1 (sICAM-1) levels,and adverse reactions.Results The total effective rate of the treatment group was 95.00％,which was higher than the control group's 80.00％,with statistical significance (P<0.05).The systolic and diastolic blood pressure in both groups after treatment were significantly lower than before treatment,and the systolic blood pressure (110.73±8.11) mmHg and diastolic blood pressure (79.25±5.03) mmHg in the treatment group were better than those in the control group (134.55±8.25) mmHg and (97.56±5.23) mmHg,with statistical significance (P<0.05).The levels of nitric oxide (NO) and endothelin (ET-1),two indicators of vascular endothelial injury,improved after treatment,and the improvement of NO (78.98±3.58) mol/L and ET-1 levels (51.22±4.56) μ g/L in the treatment group was greater than that in the control group (71.55±4.21) mol/L and (60.32±8.27) μ g/L,with statistical significance (P<0.05).Both groups showed a decrease in IMT,plasma sICAM-1,and serum Hcy levels after treatment.The treatment group had a greater decrease in IMT (1.02±0.08) mm,plasma sICAM-1 (7.21±1.01) μ mol/L,and serum Hcy levels (321.52±22.56) g/L than the control group (1.13±0.11) mm,(9.02±1.02) μ mol/L,and (370.12±25.35) g/L,with statistical significance (P<0.05).Conclusion Qingxuan Huoluo Jiangya Decoction has shown good efficacy in improving clinical symptoms,lowering blood pressure,and improving endothelial function in patients with phlegm stasis type H-type hypertension,and has good safety.
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