目的 探讨抗致密细斑点70抗体/晶状体上皮源性生长因子(dense fine speckles 70/lens epithelium-derived growth factor，DFS70/LEDGF)抗体与自身免疫性疾病(autoimmune disease，AID)的临床相关性。方法 选取2022年8月—2023年8月广西壮族自治区人民医院收治的64例致密细斑点型(dense fine speckled，DFS)ANA阳性标本作为研究对象(DFS阳性组)，另选取64名健康标本(健康组)。分析DFS阳性组临床疾病分布特点，再根据是否为AID，将DFS阳性组分为AID组(n=26)及非AID组(n=38)，分析临床疾病分布特点。比较DFS阳性组与健康组抗DFS70抗体阳性检出率。比较AID组与非AID组抗DFS70抗体阳性检出率。结果 64例DFS阳性者包括类风湿性关节炎19例(29。69％)、高血压6例(9。38％)、肺炎4例(6。25％)、面部皮炎或唇炎4例(6。25％)等。AID组包括类风湿性关节炎16例(61。54％)、干燥综合征3例(11。54％)、结缔组织病2例(7。69％)等。非AID组包括类风湿性关节炎3例(7。89％)、强直性脊柱炎1例(2。63％)、高血压6例(15。79％)、肺炎4例(10。53％)、面部皮炎或唇炎4例(10。53％)等。DFS阳性组抗DFS70抗体阳性检出25例(39。06％)，健康组检出1例(1。56％);DFS阳性组抗DFS70抗体阳性检出率高于健康组，差异有统计学意义(P<0。001)。AID组和非AID组检出抗DFS70抗体阳性共25例，其中AID组检出12例(46。15％)，非AID组检出13例(34。21％)，差异无统计学意义(P=0。336)。结论 抗DFS70/LEDGF抗体与自身免疫病临床存在相关性。
Study on the Clinical Correlation Between Anti-DFS70/LEDGF Antibodies and Autoimmune Diseases
Objective To investigate the clinical correlation between anti-dense fine speckles 70 antibodies/lens epithelium-derived growth factor (DFS70/LEDGF) antibodies and autoimmune diseases (AID). Methods Selected 64 dense fine speckled (DFS) ANA positive specimens admitted to the People's Hospital of Guangxi Zhuang Autonomous Region from August 2022 to August 2023 as the research objects (DFS positive group). Additionally,64 healthy specimens were selected as the healthy group. The clinical disease distribution characteristics of DFS positive group were analyzed,and according to whether it was an AID,the DFS positive group was divided into an AID group (n=26) and a non AID group (n=38),and the clinical disease distribution characteristics was analyzed. The positive detection rate of anti-DFS70 antibody was compared between DFS positive group and healthy group. The positive detection rate of anti-DFS70 antibody in AID group and non-AID group was compared. Results The 64 cases with positive DFS included 19 cases of rheumatoid arthritis (29.69％),6 cases of hypertension (9.38％),4 cases of pneumonia (6.25％),and 4 cases of facial dermatitis or cheilitis (6.25％),among which rheumatoid arthritis accounted for the highest proportion. There were 16 cases of rheumatoid arthritis (61.54％),3 cases of Sjögren syndrome(11.54％),and 2 cases of connective tissue disease (7.69％) in the AID group. The non-AID group included 3 cases of rheumatoid arthritis (7.89％),1 case of ankylosing spondylitis (2.63％),6 cases of hypertension (15.79％),4 cases of pneumonia (10.53％),4 cases of facial dermatitis or cheilitis (10.53％),etc. Anti-DFS70 antibody was detected in 25 cases (39.06％) in DFS positive group and 1 case (1.56％) in healthy group. The positive rate of anti-DFS70 antibody in DFS positive group was higher than that in healthy group,and the difference was statistically significant (P<0.001). A total of 25 cases of positive anti-DFS70 antibody were detected in AID group and non-AID group,of which 12 cases (46.15％) were detected in AID group and 13 cases (34.21％) were detected in non-AID group,and the difference was not statistically significant (P=0.336). Conclusion Anti-DFS70/LEDGF antibodies are clinically correlated with autoimmune diseases.
万方数据
维普
