Application Effect of Levocarnitine Combined With Hemodialysis in the Treatment of Chronic Renal Failure
Objective To investigate the effect of levocarnitine combined with hemodialysis in the treatment of CRF.Methods A total of 70 patients with CRF admitted to the department of nephrology,rheumatology and immunology in Bayingolin Mongolian Autonomous Prefecture People's Hospital,Xinjiang Uygur Autonomous Region from May 2021 to May 2023 were selected as the study objects.The patients were divided into control group and treatment group by random sampling,35 cases in each group.The control group received hemodialysis therapy,based on this basis,the treatment group received levocarnitine.The clinical efficacy,renal function,inflammatory factors,adverse reactions and cardiac function of the two groups were compared.Results The total effective rate of the treatment group was 97.14%(34/35),which was higher than 77.14%(27/35)of the control group,the difference was statistically significant(P<0.05).After treatment,serum creatinine(Scr)and blood urea nitrogen(BUN)in the treatment group were(245.18±14.52)mmol/L and(13.56±1.20)mmol/L,respectively,which were lower than(325.20±17.20)mmol/L and(16.20±2.55)mmol/L in the control group,endogenous creatinine clearance rate(Ccr)in the treatment group was(45.55±10.20)mL/min,which was higher than(35.20±6.33)mL/min in the control group,the differences were statistically significant(P<0.05).After treatment,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),matrix metalloproteinase(MMP-9)in the treatment group were lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After treatment,left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)and cardiac index(CI)in the treatment group were lower than those in the control group,and left ventricular ejection fraction(LVEF)was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion Levocarnitine combined with hemodialysis in the diagnosis and treatment of CRF has a significant effect,which can control the micro-inflammatory state of the body,improve heart and kidney function.
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