Effects of Tolvaptan on Cardiac Function and Vascular Endothelial Function in Elderly Patients With Chronic Heart Failure
Objective To investigate the effects of treatment with tolvaptan on cardiac function and vascular endothelial function in elderly patients with chronic heart failure(CHF).Methods A total of 72 elderly patients with CHF admitted to the department of cardiovascular medicine,People's Hospital of Shaodong from January 2022 to December 2023 were selected and divided into control group(n=36)and observation group(n=36)by random number table method.The control group was treated with conventional diuretic drugs(furosemide tablets),and the observation group was treated with tolvaptan.The clinical efficacy,serum nterminal pro-brain natriuretic peptide(NT-proBNP),serum sodium level,cardiac function and vascular endothelial function were compared between the two groups of CHF patients.Results The total effective rate of the observation group was 94.44%,which was higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the level of NT-proBNP in the observation group was(810.27±45.68)μg/L,which was lower than(1 247.63±51.17)μg/L in the control group,and the serum sodium level in the observation group was(139.25±5.51)mmol/L,which was higher than(134.81±4.98)mmol/L in the control group,and the differences were statistically significant(P<0.05).The level of left ventricular ejection fraction(LVEF)in the observation group was(51.75±2.84)%,which was higher than(48.36±3.25)%in the control group,the left ventricular end-diastolic diameter(LVEDD)and left ventricular end systolic diameter(LVESD)levels in the observation group were(53.98±7.31)mm and(45.23±4.45)mm,respectively,which were lower than(57.56±6.07)mm and(49.61±4.32)mm in the control group,the differences were statistically significant(P<0.05).The nitric oxide(NO)and calcitonin gene related peptide(CGRP)levels in the observation group were(80.12±6.32)μmol/L and(49.25±4.67)mg/L,respectively,which were higher than(65.12±3.45)μmol/L and(35.26±3.17)mg/L in the control group,the endothelin(ET)level in the observation group was(70.47±5.47)ng/L,which was lower than(85.24±6.29)ng/L in the control group,the differences were statistically significant(P<0.05).Conclusion Torvaptan has significant clinical efficacy in the treatment of elderly patients with CHF,effectively improving cardiac function indicators,and helping to restore vascular endothelial function to normal state.
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