Clinical Study on the Treatment of Acute Ischemic Stroke With Hirudo Powder Combined With in Vitro Cultured Calculus Bovis
Objective To explore the clinical effect of hirudo powder combined with in vitro cultured calculus bovis in the treatment of acute ischemic stroke.Methods A total of 66 inpatients with acute ischemic stroke admitted to the department of encephalopathy,Yangjiang Hospital of Traditional Chinese Medicine from January 2023 to June 2024 were eligible and were randomly divided into an observation group and a treatment group,with 33 cases in each group.The observation group received conventional therapy,while the treatment group was treated with hirudo powder combined with in vitro cultured calculus bovis on the basis of the observation group.The neurological function[(National Institutes of Health Stroke scale score(NIHSS)],clinical symptoms,and activities of daily living[(Barthel index(BI)]were compared before treatment,7 and 14 days after treatment between the two groups.The laboratory indicators[high-sensitivity C-reactive protein(hs-CRP),plasma protein C(PC)activity,antithrombin Ⅲ(AT-Ⅲ)activity]before treatment and 14 days after treatment were evaluated.And the therapeutic effect of hirudo powder combined with in vitro cultured calculus bovis on acute ischemic stroke and the incidence of adverse reactions during the medication period were assessed.Results After 7 and 14 days of treatment,the NIHSS scores of the treatment group were(7.29±1.03)points and(4.71±0.79)points,which were lower than(10.44±1.13)points and(7.36±0.95)points of the observation group,respectively,the clinical symptom scores of the treatment group were(18.56±3.55)points and(14.09±3.11)points,which were lower than(22.78±3.76)points and(18.14±3.23)points of the observation group,respectively.the scores of daily living ability of the treatment group were(64.28±6.85)points and(75.69±7.28)points,respectively,which were higher than(55.83±7.29)points and(67.44±8.44)points of the observation group,and the differences were statistically significant(P<0.05).After 14 days of treatment,the hs-CRP level of the treatment group was(7.29±1.86)mg/L,which was lower than(13.77±2.41)mg/L of the observation group,the activity of PC and AT-Ⅲ of the treatment group were(98.44±5.71)%and(99.27±2.23)%,respectively,which were higher than(92.59±6.62)%and(95.44±2.06)%of the observation group,the differences were statistically significant(P<0.05).The total effective rate of the treatment group was 93.94%,which was higher than 75.76%of the observation group,and the difference was statistically significant(P<0.05).No serious adverse reactions occurred in both groups.Conclusion The treatment of acute ischemic stroke with hirudo powder combined with in vitro cultured calculus bovis has significant clinical effects,which can effectively improve the neurological function,clinical symptoms,and daily living ability of patients,and its mechanism of action may be related to the down-regulation of inflammatory factors and the enhancement of PC activity and AT-Ⅲ activity.
acute ischemic strokehirudocalculus bovisneurological functioninflammatory factorsplasma protein Cantithrombin Ⅲ
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维普
