Correlation of γ-aminobutyric acid with serum tumor markers and its prognostic value in esophageal squamous cell carcinoma
Objective To analyze the correlation of γ-aminobutyric acid(GABA)with serum tumor markers,and its prognostic value in patients with esophageal squamous cell carcinoma(ESCC).Methods A retrospective analysis was con-ducted on 112 patients with ESCC who were treated in The First Affliated Hospital of Nanyang Medical College from May 2021 to May 2022.The levels of GABA and various serum tumor markers,and long-term survival were compared among them by TNM stage[32 in early stage(stage 0-Ⅰ),45 in middle stage(stage Ⅱ-Ⅲ),35 in advanced stage(stage Ⅳ)].The correlation between GABA and various serum tumor markers was verified using the Spearman correlation coeficient.The predictive value of GABA level for the prognosis of ESCC patients was evaluated by plotting the receiver operating char-acteristic(ROC)curve.Results The differences in GABA,GEA,CA199,and CA724 levels across early,middle and advanced stage groups were statistically significant(P＜0.05).And the levels of the above-mentioned four markers in ad-vanced stage group were all higher than those of the other two groups(P＜0.05).During the follow-up period,23 cases in the advanced stage group had disease progression,among whom 13 had endpoint events;15 cases in the middle stage group had disease progression,among whom 7 had endpoint events;10 cases in the early stage group had disease progression,among whom 4 had endpoint events.The differences in median progression-free survival(PFS),median overall survival(OS),and average modified Glasgow Prognostic Score(mGPS)among the three groups were statistically significant(P＜0.05).The advanced-stage group had shorter median PFS and median OS,and higher average mGPS score than the other two groups(P＜0.05).The Spearman correlation test showed that as the GABA level increased,the levels of various serum tumor markers also increased correspondingly(P＜0.05).ROC curve analysis indicated that higher GABA level was associ-ated with shorter survival and worse prognosis(AUC＞0.85).Conclusion The GABA level in patients with ESCC can con-tinuously increase with the upregulation of the expression levels of various serum tumor markers,and the changes in GABA level are closely related to the patient's prognosis,suggesting a high prognostic value.
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