Determination of indium in plasma by inductively coupled plasma-mass spectrometry
Objective To establish an inductively coupled plasma mass spectrometry(ICP-MS)for the determination of indium in plasma by studying the sensitivity of different diluents.Methods 1 ml plasma was filled to 10 ml with 0.2％ HNO3-0.05％ Triton X-100(V/V)diluent,and the concentration of indium in plasma was determined by ICP-MS.Results The plasma samples had a good linear relationship in their reasonable range,with the correlation coefficient of 0.999 4,with the detection limit of 0.000 1 μg/L,and the minimum detectable concentration of 0.001 μg/L.The average spiked recoveries of indium in plasma were 98.3％ -108.0％ ,the intra-batch precision was 0.5％ -4.5％ ,and the inter-batch precision was 4.5％ .The average concentration of indium in plasma samples of normal control population(n=15)was 0.026 μg/L,and that of indium miners(n=15)was 0.390 μg/L.Conclusion The ICP-MS can be used for the determina-tion of indium concentration in plasma through detecting indium in directly diluted plasma with low detection limit,high sensitivi-ty and good precision.
IndiumPlasmaInductively coupled plasma mass spectrometry
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