东莞市新生儿苯丙酮尿症筛查的卫生经济学评价研究
Health Economic Evaluation of Neonatal Phenylketonuria(PKU)Screening in Dongguan/
陈国祝 1邹俐爱 2黄小玲 1钟诗颖 3袁薇1
作者信息
- 1. 东莞市妇幼保健院 广东 东莞 523110
- 2. 南方医科大学附属南方医院 广州 510515
- 3. 东莞市第八人民医院(东莞市儿童医院) 广东 东莞 523321
- 折叠
摘要
目的:评估东莞市新生儿苯丙酮尿症(PKU)筛查项目的实施效果,对其开展卫生经济学评价,为东莞市新生儿遗传缺陷的防控政策提供参考.方法:以2012年1月—2021年12月在东莞市出生确诊的PKU患儿为对象,通过东莞新生儿疾病筛查中心随访、问卷调查等获得相关数据,对东莞市新生儿PKU筛查防治工作进行成本-效益、成本-效果分析.结果:东莞市新生儿PKU共筛查1 245 243例,平均筛查率为93.32％,确诊PKU 29例,阳性率为1:42 939,持续随访23例,除1例患儿智力在临界值外,其余均发育正常;筛查总成本为2 972.87万元,总效益为14 239.90万元,成本-效果比为102.51:1,成本-效益比1:4.79.结论:东莞市新生儿PKU筛查的社会效益与经济效益明显,全周期持续开展并不断完善筛查工作的管理政策意义重大.
Abstract
Objective:To acquire the implementation effect of the neonatal Phenylketonuria(PKU)Screening Project in Dong-guan,and evaluate its economic effectiveness,so as to provide references for the prevention and control policies of genetic defects in newborns.Methods:Choosing PKU children born in Dongguan from January 2012 to December 2021(excluding BH4 deficien-cy)as the subjects,conduct the cost-benefit and cost-effectiveness analysis on the prevention and treatment of PKU.The relevant data was gained from questionnaire surveys,statistical data,medical service prices of non-profit medical institutions in Dongguan,and relevant literature materials.Results:In the past 10 years,1 245 243 newboms were screened for PKU in Dongguan,the average screening rate is 93.32％.Among them,29 were diagnosed with PKU,with a positive rate of 1:42939.During continuous follow-up,23 cases were diagnosed.Among the 23 follow-up cases,only 1 had intelligence at the critical value,while the rest were normal.The total cost of screening is 29.728 7 million,and the total benefit is 14.239 9 million.The cost-effectiveness ratio is 102.51:1,the cost-benefit ratio is 1:4.79.Conclusion:Neonatal phenylketonuria(PKU)screening in Dongguan has significant social and economic benefits.It's necessary to continue and improve the screening work,especially the policy which can benefit the PKU's full life.
关键词
新生儿/苯丙酮尿症/卫生经济学评价/东莞Key words
neonatal/phenylketonuria/health economics evaluation/Dongguan引用本文复制引用
基金项目
广东省卫生经济学会项目(2021-WJMZ-42)
出版年
2024
NETL
NSTL
万方数据