Distribution and drug resistance analysis of pathogenic bacteria from blood culture of pediatric patients
Objective This paper aims to investigate the distribution and drug resistance of pathogenic bacteria in blood culture of hospitalized children and provide reference for reasonable use of antibiotics in clinical practice.Methods The main patho-gens and their drug resistance were analyzed retrospectively in blood culture samples of pediatric patients.Results A total of 9 515 blood culture samples were collected,259 strains of pathogenic bacteria were detected,and the positive rate was 2.7％,including 157 strains of gram-positive bacteria(60.6％)and 102 strains of gram-negative bacteria(39.4％).The main pathogens were coagulase negative Staphylococcus,Klebsiella pneumoniae,Escherichia coli,Staphylococcus aureus,Enterococ-cus.The results of drug sensitivity showed that the resistance rate of Staphylococcus to penicillin,erythromycin and clindamycin was high,and no Staphylococcus and Enterococcus resistant to vancomycin and linezolid was detected.The resistance rates of Klebsiella pneumoniae and Escherichia coli to ampicillin,cefazolin,cefuroxime and ceftriaxone were high,and their resistance rates to carbapenems,amikacin,piperacillin/tazobactam were low.Conclusion Gram-positive bacteria are the main patho-gens of blood culture of hospitalized children,the drug resistance of pathogenic bacteria is severe,and the distribution of patho-genic bacteria and drug resistance should be monitored timely in order to select an optimal antimicrobial therapy.
NETL
NSTL
万方数据
维普
