Analysis of co-expressed differential genes in bipolar disorder and schizophrenia
Objective This paper aims to utilize bioinformatics to search for the co-expression differential gene(DEG)in bi-polar disorder(BD)and schizophrenia(SCZ).Methods Differentially expressed genes in BD and SCZ were selected from GSE53987 and GSE35977 datasets,compared with normal controls,and the co-expressed DEG genes were selected for GO/KEGG analysis.The protein interaction was analyzed by STRING database and hub genes were screened.The diagnostic value of hub genes for BD and SCZ was analyzed by ROC curve.Results A total of 60 co-expressed DEGs were screened.GO/KEGG enrichment analysis showed that the co-expressed DEGs were mainly concentrated in brain neurons,and most of them were involved in the biological processes of synaptic organization,differentiation and transmission.KEGG analysis showed that amyotrophic lateral sclerosis,P13K-Akt signaling pathway,MAPK signaling pathway,and mTOR signaling pathway were mainly involved.The selected hub genes(EGF,FGF2,NTRK2,SLC1A3 and SNAP25)had certain accuracy in the diagnosis of BD and SCZ.Conclusion BD and SCZ have co-expressed DEG,which plays an important role in the occurrence and pro-gression of BD and SCZ through multiple signaling pathways.
NETL
NSTL
万方数据
维普
