颅脑损伤患者去骨瓣减压术后C-反应蛋白/白蛋白比值变化及临床意义
Changes and clinical significance of C-reactive protein/albumin ratio in patients with craniocerebral injury after decompressive craniectomy
吴云龙 1林聪利 2雷兵3
作者信息
- 1. 浙江省仙居县中医院神经外科,浙江 317300
- 2. 浙江省仙居县中医院外科
- 3. 浙江省人民医院神经外科
- 折叠
摘要
目的 研究颅脑损伤患者去骨瓣减压术后C-反应蛋白/白蛋白比值(CRP/ALB)变化及临床意义.方法 选取医院于2020年10月-2022年4月拟行去骨瓣减压术治疗的重型颅脑损伤患者进行前瞻性研究.分别于术前、术后1 d、术后3 d、术后5 d、术后7 d测定患者C-反应蛋白(CRP)、白蛋白(ALB)水平.于术后14 d,采用格拉斯哥预后评分(GOS)评价颅脑损伤患者预后情况,统计患者术后CRP/ALB比值变化情况,并比较不同预后患者术后CRP/ALB数值变化,并分析术后CRP/ALB数值与患者预后的关系.结果 去骨瓣减压术后重型颅脑损伤患者CRP、CRP/ALB水平上升,ALB数值下降,且在术后3 d时,CRP、CRP/ALB数值上升至顶峰,后逐渐下降;ALB数值下降至低谷,后逐渐回升;术后,90例颅内损伤患者中预后良好39例,占比43.33％.预后良好组术前、术后1 d、术后3 d、术后5 d、术后7 d时CRP/ALB数值均小于预后不良组,差异有统计学意义(P＜0.05);经点二列相关结果显示,CRP/ALB数值与颅脑损伤患者预后情况成负相关(P＜0.05).结论 颅脑损伤患者去骨瓣减压术后CRP/ALB变化与患者预后有关,其值越低,代表患者预后越好.
Abstract
Objective This paper aims to study the changes and clinical significance of C-reactive protein/albumin ratio(CRP/ALB)in patients with craniocerebral injury after decompressive craniectomy.Methods The patients with severe cranio-cerebral injury who were scheduled to undergo decompressive craniectomy from October 2020 to April 2022 were selected for a prospective study.The levels of C-reactive protein(CRP)and albumin(ALB)were measured before operation,1 day after operation,3 days after operation,5 days after operation and 7 days after operation.On the 14th day after operation,Glasgow Outcome Scale(GOS)was used to evaluate the prognosis of patients with craniocerebral injury,and the change of CRP/ALB ratio after operation was counted.The changes of CRP/ALB values in patients with different prognosis were compared,and the relationship between the CRP/ALB values after operation and the prognosis of patients was analyzed.Results CRP and CRP/ALB levels increased and ALB values decreased in patients with severe craniocerebral injury after decompressive craniectomy,and CRP and CRP/ALB values increased to the peak at 3 days after surgery,and then decreased gradually.The ALB value decreased in a low point and then increased gradually.After operation,39 of 90 patients with intracranial injury had a good prognosis,accounting for 43.33％.The CRP/ALB values before operation,1 day after operation,3 days after operation,5 days after operation and 7 days after operation in the group with good prognosis were lower than those in the group with poor prognosis,with the difference statistically significant(P＜0.05).The results of binary correlation showed that CRP/ALB values were negatively correlated with the prognosis of patients with craniocerebral injury(P＜0.05).Conclusion The change of CRP/ALB after decompressive craniectomy is related to the prognosis of patients with craniocerebral injury.The lower the value,the better the prognosis of patients.
关键词
颅脑损伤/去骨瓣减压术/C-反应蛋白/白蛋白Key words
Craniocerebral injury/Decompressive craniectomy/C-reactive protein/Albumin引用本文复制引用
出版年
2023
NETL
NSTL
维普
万方数据