The predictive value of serum triacylglycerol,cystatin C and glucose transporter 5 levels for hyperuricemia in patients with IgA nephropathy
Objective This paper aims to explore the predictive value of serum triacylglycerol(TG),cystatin C(Cys-C)and glucose transporter 5(GLUT5)levels on hyperuricemia in patients with primary immunoglobulin A(IgA)nephropathy.Methods A total of 120 patients with IgA nephropathy in our hospital from January 2021 to December 2022 were divided into hyperuricemia group(n=57)and non-hyperuricemia group(n=63)according to the blood uric acid(BUA)level.General data,expression of serum TG,Cys-C and GLUT5,CKD staging of the two groups were compared,and the correlation between BUA and serum TG,Cys-C and GLUT5 was analyzed,as well as the predictive value of each index for hyperuricemia in IgA nephropathy patients.Results The levels of serum BUA,TG,Cys-C and GLUT5 in hyperuricemia group were higher than those in non-hyperuricemia group(P＜0.05).BUA was positively correlated with serum TG,Cys-C and GLUT5 levels(P＜0.05).There was statistical significance on the difference in CKD stages between the two groups(P＜0.05).The AUC of serum TG,Cys-C and GLUT5 in predicting the occurrence of hyperuricemia was 0.893,the sensitivity was 70.18％,and the specificity was 95.24％,AUC and specificity were better than the individual predictive value of each index(P＜0.05).Conclusion TG,Cys-C,GLUT5 have certain correlation with BUA level in patients with IgA nephropathy and hyperurice-mia.The combined detection of TG,Cys-C and GLUT5 has good predictive value for the occurrence of hyperuricemia in patients with IgA nephropathy,which can provide reliable theoretical basis for clinical diagnosis and improvement of prognosis.
IgA nephropathyTriacylglycerolCystatin CGlucose transporter 5HyperuricemiaPredictive value
NETL
NSTL
万方数据
维普
