Correlation of serum granulocyte colony-stimulating factor,interleukin-1βand vascular cell adhesion molecule-1 levels with neurological injury and prognosis in children with severe viral encephalitis
Objective This paper aims to observe the changes of serum granulocyte colony-stimulating factor(G-CSF),interleukin-1β(IL-1β)and vascular cell adhesion molecule-1(VCAM-1)levels in children with severe viral encephali-tis(SVE)and analyze the correlation of G-CSF,IL-1 β and VCAM-1 with nerve injury and prognosis.Methods A total of 89 children with SVE admitted to our hospital from August 2019 to December 2022 were selected as the SVE group,and 75 healthy children who underwent physical examination during the same period were selected as the control group.Serum G-CSF,IL-1β,VCAM-1,nerve injury indexes[creatine kinase brain isoenzyme(CK-BB),myelin basic protein(MBP),neuron-specific enolase(NSE)]were compared between the two groups.Pearson correlation analysis was used to evaluate the correlation between serum G-CSF,IL-1β,VCAM-1 and nerve injury in children with SVE.Receiver operating charac-teristic(ROC)curve was drawn to analyze the prognostic value of serum G-CSF,IL-1 β and VCAM-1 in children with SVE.Results The levels of G-CSF,IL-1 β and VCAM-1 in SVE group were higher than those in control group(P＜0.05).The serum levels of CK-BB,MBP and NSE in SVE group were higher than those in control group(P＜0.05).Serum G-CSF,IL-1β and VCAM-1 levels were positively correlated with CK-BB,MBP and NSE in SVE children(P＜0.05).The levels of G-CSF,IL-1β and VCAM-1 in children with poor prognosis were higher than those in children with good prognosis(P＜0.05).ROC curve showed that the AUCs of G-CSF,IL-1β and VCAM-1 alone and combined were 0.839,0.776,0.852 and 0.955 in predicting poor prognosis of SVE children.Conclusion Serum G-CSF,IL-1β and VCAM-1 show high expression in children with SVE,which is closely related to the degree of nerve injury.The combined detection of these three indexes has good predictive efficacy for poor prognosis in children with SVE.
Severe viral encephalitisGranulocyte-colony stimulating factorInterleukin-1βVascular cell adhesion mole-cule-1
NETL
NSTL
万方数据
维普
