血清IL-6、IFN-γ联合血清SAA对成人甲型流感诊断价值的评价
Evaluation of serum interleukin-6 and interferon-γ combined with serum amyloid A in the diagnosis of influenza A in adults
劳俊杰 1项国谦 2赵洪灿2
作者信息
- 1. 浙江中医药大学第四临床医学院,浙江杭州 310053;浙江大学医学院附属杭州市第一人民医院
- 2. 浙江大学医学院附属杭州市第一人民医院
- 折叠
摘要
目的 探讨血清白细胞介素-6(IL-6)、干扰素-γ(IFN-γ)联合血清淀粉样蛋白A(SAA)对成年人甲型流感的诊断价值.方法 选取2023年3月杭州市第一人民医院发热门诊收治的成人甲型流感患者60例(甲流组),普通流感患者60例(普通流感组),健康者60例(对照组).检测各组血清IL-6、IFN-γ、血清SAA水平.应用受试者工作特征曲线(ROC)分析血清IL-6、IFN-γ联合血清SAA对成年人甲型H1N1流感诊断的参考价值.采用Spearman相关分析探讨血清IL-6、IFN-γ水平与血清SAA水平的相关性.结果 甲流组和普通流感组血清IL-6、IFN-γ、血清SAA水平均高于对照组(P＜0.05).ROC曲线显示,血清IL-6诊断甲流的ROC曲线下面积(AUC)为0.688(95％CI:0.612～0.763),最佳诊断临界值为 3.465 pg/ml;血清 IFN-γ诊断甲流的 AUC 为 0.663(95％CI:0.586～0.740),最佳诊断临界值为0.95 IU/ml;血清SAA诊断甲流的AUC为0.796(95％CI:0.733～0.853),最佳诊断临界值为15.950 mg/L;血清 IL-6、SAA 联合诊断 AUC 为 0.808(95％CI:0.747～0.869);血清 IFN-γ、SAA 联合诊断 AUC 为0.766(95％CI:0.690～0.842).甲流组血清IL-6水平与血清SAA水平成正相关关系(r=0.388,P＜0.01),血清IFN-γ水平与血清SAA水平无关.结论 甲型流感成人患者的血清IL-6、IFN-γ、血清淀粉样蛋白A水平升高,血清IL-6联合SAA联合检测对成人甲流的诊断具有一定参考价值.
Abstract
Objective This paper aims to investigate the diagnostic value of serum interleukin-6(IL-6),interferon-γ(IFN-γ)and serum amyloid A(SAA)in adults with.influenza A.Methods A total of 60 adult influenza A patients(influ-enza A group),60 common influenza patients(common influenza group)and 60 healthy people(control group)were selected from the fever clinic of Hangzhou First People's Hospital in March 2023.Serum levels of IL-6,IFN-γ and SAA in each groups were detected.The reference value of serum IL-6 and IFN-γ combined with serum SAA in the diagnosis of adult influ-enza A(H1N1)was analyzed by receiver operating characteristic curve(ROC).Spearman correlation analysis was used to investigate the correlation between serum IL-6 and IFN-γ levels and serum SAA levels.Results The serum levels of IL-6,IFN-γ and SAA in influenza A group and common influenza A group were higher than those in control group(P＜0.05).ROC curve showed that the area under ROC curve(AUC)of serum IL-6 for the diagnosis of swine flu was 0.688(95％CI:0.612-0.763),and the optimal diagnostic critical value was 3.465 pg/ml.The AUC of serum IFN-γ was 0.663(95％CI:0.586-0.740),and the optimal diagnostic critical value was 0.95 IU/ml.The AUC of serum SAA was 0.796(95％CI:0.733-0.853),and the optimal diagnostic threshold was 15.950 mg/L.The AUC of serum IL-6 combined with SAA was 0.808(95％CI:0.747-0.869).The AUC for the combined diagnosis of serum IFN-γ and SAA was 0.766(95％CI:0.690-0.842).Serum IL-6 level was positively correlated with serum SAA level(r=0.388,P＜0.01),and serum IFN-γ level was not significantly correlated with serum SAA level.Conclusion The levels of serum IL-6,IFN-γ and serum amyloid protein A in adult patients with influenza A are significantly increased.The combined detection of serum IL-6 and SAA is of certain reference value for the diagnosis of adult influenza A.
关键词
甲型流感/成年人/白细胞介素-6/干扰素-γ/血清淀粉样蛋白AKey words
Influenza A/Adult/Interleukin-6/Interferon-γ/Serum amyloid A引用本文复制引用
基金项目
浙江省卫健委医药卫生科技计划面上项目(2020KY-207)
出版年
2023
NETL
NSTL
维普
万方数据