Diagnostic value of combined detection of interleukin-33,lymphocyte ratio,adenosine deaminase in pleural effusion and peripheral blood tuberculosis-interferon-gamma release assays for tuberculous pleurisy
Objective This paper aims to explore the significance of combined detection of interleukin-33(IL-33),lympho-cyte ratio,adenosine deaminase in pleural effusion and peripheral blood tuberculosis-interferon-gamma release assays(TB-IGRA)in the diagnosis of tuberculous pleurisy.Methods A total of 86 patients with tuberculous pleurisy who were first admit-ted to hospital from January 2020 to December 2022 were collected as the research group,and 71 patients with non-tuberculous pleurisy were selected as the control group.The IL-33,lymphocyte ratio,adenosine deaminase in pleural effusion and periph-eral blood TB-IGRA were compared between the two groups,and the ROC curve was used to compare the diagnostic efficacy of single and combined detection of the indicators for tuberculous pleurisy.Results The levels of pleural effusion IL-33,lym-phocyte ratio,adenosine deaminase and peripheral blood TB-IGRA in the tuberculous pleurisy group were higher than those in the control group(P＜0.05),and the area under the ROC curve(AUC)were 0.783,0.720,0.820 and 0.837;the sensitivi-ty were 79.5％,70.9％,85.7％,and 86.6％;the specificity were 71.8％,67.6％,69.0％and 73.2％.AUC,sensitivity and specificity of combined detection were 0.908,90.2％,and 85.9％,respectively,and the diagnostic efficiency was signifi-cantly improved.Conclusion In the diagnosis of tuberculous pleurisy,the combined detection of IL-33,lymphocyte ratio,adenosine deaminase and peripheral blood TB-IGRA in pleural effusion can significantly improve the diagnostic efficiency,which is an ideal choice for the diagnosis of tuberculous pleurisy.
NETL
NSTL
万方数据
维普
