Detection and significance of fibrin degradation product,serum procalcitonin and C-reactive protein in severity and prognosis of elderly patients with severe pneumonia
Objective This study aims to explore the significance of fibrin degradation product(FDP),serum procalcitonin(PCT)and C-reactive protein(CRP)detection in the severity and prognosis of elderly patients with severe pneumonia.Methods Fifty-four patients with severe pneumonia admitted to our hospital from January to December 2022 were selected.According to the different prognosis of patients on the 28th day after admission,the patients with poor prognosis were taken as the study group and those with good prognosis as the control group.The levels of FDP,PCT and CRP were measured and compared with SPSS 26.0 and Graphpad Prism7.0.ROC receiver operating curve was plotted to draw the area under the curve(AUC),detect sensitivity and specificity,and compare the diagnostic performance of each indicator for severe pneumonia.Logistic pro-portional hazard model was used to analyze the risk factors of prognosis of severe pneumonia patients with corresponding indica-tors.Results FDP and PCT in the study group were higher than those in the control group,and the difference was statistically significant(P＜0.05).Logistic regression analysis showed that FDP was a risk factor for poor prognosis in patients with severe pneumonia(OR=1.185,95％CI:1.03-1.365,P＜0.05).The ROC curve is drawn according to whether the patients with severe pneumonia died during hospitalization,the area under the curve,sensitivity and specificity of FDP in predicting the prog-nosis of patients with severe pneumonia are the highest,which are 0.877(95％CI:0.783-0.971),95.24％and 78.79％respectively,which are superior to other single tests.Conclusion FDP and PCT are related to the severity and prognosis of patients with severe pneumonia,which can be used as indicators for evaluating the condition of severe pneumonia and have im-portant clinical value for evaluating the prognosis.
Fibrin degradation productSerum procalcitoninC-reactive proteinSenile severe pneumoniaPrognosis
NETL
NSTL
万方数据
维普
