A study on the correlation between fat-soluble vitamins and the severity of Tourette's syndrome in children and on the evaluation of intervention effects
Objective This paper aims to analyze the correlation between serum fat-soluble vitamins and the severity of Tourette syndrome(TS)in children and evaluate the effect of vitamin D3 supplementation on the severity of TS.Methods Eighty two children with TS were used as the study group and sixty six healthy children as the control group,and the differences of fat-soluble vitamins were compared.The study group was further divided into mild group(n=50)and moderate-severe group(n=32),and the differences in the scores of Yale Comprehensive Tic Severity Scale(YGTSS)and the level of fat-soluble vitamins were compared,and the correlation between the severity of the disease and the level of fat-soluble vita-mins was analyzed.Children who meet the standard of vitamin D deficiency or deficiency in mild cases were selected as the intervention group(n=36),and vitamin D3 intervention and effect evaluation were carried out.Results The difference in the serum level of 25-hydroxyvitamin D[25(OH)D]between the study group and the control group was statistically significant(P＜0.001),and that in the study group was significantly decreased.There was statistical significance on the difference between mild group and moderate-severe group in YGGTSS score and 25(OH)D level(P＜0.001).The YGGTSS score in moderate-severe group was higher than that in mild group,and the 25(OH)D level was lower than that in mild group.There was a negative correlation between the severity of the disease and the 25(OH)D level(r=-0.791,P＜0.001).After oral vitamin D3 intervention,the YGTSS score decreased and the level of25(OH)D increased.Conclusion Vitamin D deficiency in children is closely related to TS,and the severity of TS is negatively correlated with the level of 25(OH)D.Vitamin D3 sup-plementation can improve the condition of mild TS children with vitamin D deficiency or deficiency.
Fat-soluble vitaminsTourette's syndrome25-hydroxyvitamin D
NETL
NSTL
万方数据
维普
