目的 收集舟山地区系统性红斑狼疮(SLE)患者的实验室指标,建立SLE患者并发心脏损害的logistic风险模型并输出为Nomogram图.方法 选取2020年1月—2023年2月在本院就诊的SLE的患者共125例,其中男性4例,女性121例,平均年龄为(44.77±14.41)岁.采集血样检测血常规、生化和免疫等指标,通过logistic回归模型筛选独立风险因子,通过Nomogram图进行可视化输出.结果 125例患者中78例存在心脏损害.多因素logistic回归结果显示:抗 Sm 抗体、ESR、Cr 是 SLE 并发心脏损害的危险因素(OR=1.025,P＜0.05;OR=1.046,P＜0.05;OR=1.043,P＜0.01);C3、C4是SLE并发心脏损害的保护因素(OR=0.291,P＜0.05;OR=0.125,P＜0.05).结论 建立得到一种简单又可操作性强的预测SLE患者并发心脏损害的预测模型,有助于患者的早期诊疗.
Establishment of a Nomogram risk warning model for patients with systemic lupus erythematosus complicated by cardiac damage
Objective This study aims to establish a logistic risk model for patients with systemic lupus erythematosus(SLE)complicated by cardiac damage by collecting laboratory indicators of patients with SLE in Zhoushan area,and generate a Nomogram.Methods From Jan.2019 to Feb.2023,125 patients who were diagnosed with SLE were collected,including 4 males and 121 females with an average age of(44.77±14.41).Blood samples were collected to detect routine,biochemical and immune indicators.Independent risk factors were screened by logistic regression model,and visualized by Nomogram.Results There were 78 patients with cardiac damage among the 125 patients.Multivariable logistic regression model showed that anti-Sm,ESR,Cr were independent risk factors(OR=1.025,P＜0.05;OR=1.046,P＜0.05;OR=1.043,P＜0.01).C3 and C4 were independent protective factors(OR=0.291,P＜0.05;0.125,P＜0.05).Conclusion The estab-lished simple and operable model for predicting cardiac damage in SLE patients is helpful for the early diagnosis and treatment of SLE.
NETL
NSTL
万方数据
维普
