Expression and clinical significance of serum interleukin-8 in pregnant women with recurrent spontaneous abortion
Objective This study aims to observe the expression of serum interleukin-8(IL-8)in pregnant women with recurrent spontaneous abortion(RSA),and to explore the relationship between IL-8 level and recurrent abortion.Methods This study was a prospective analysis.70 pregnant women with RSA who were hospitalized in the First People's Hospital of Linping District,Hangzhou from January 2020 to December 2022 were collected as the study group,and 70 normal pregnant women who were registered in our hospital during the same period as the control group.The pregnant women were followed up till the end of pregnancy.All pregnant women underwent the test of serum IL-8 level,and the study group was divided into high IL-8 group and low IL-8 group based on the median IL-8 level.The incidence of recurrent abortion in pregnant women with RSA in high IL-8 group and low IL-8 group was compared,and the serum IL-8 levels of pregnant women with recurrent abortion and non-abortion were compared.The relationship between serum IL-8 level and recurrent abortion in RSA pregnant women was tested by point two column correlation.Logistic regression analysis was used to test the risk factors of recurrent abortion in RSA pregnant women.Receiver operating characteristic(ROC)curve analysis was used to test the predictive value of serum IL-8 level for recurrent abortion in RSA pregnant women.Results The serum IL-8 level of pregnant women in the study group was significantly higher than that in the control group,with the difference statistically signifi-cant(P＜0.05).The median serum IL-8 level of pregnant women in the study group was 154.74 pg/ml.According to the median level,pregnant women were divided into high IL-8 group(serum IL-8 level ≥154.74 pg/ml)and low IL-8 group(serum IL-8 level＜154.74 pg/ml),with 3 5 RSA pregnant women in each group.The follow-up results showed that the abortion rate in the high IL-8 group was 54.29％,higher than 28.57％in the low IL-8 group,with the difference statistically significant(P＜0.05).By point binary correlation analysis,serum IL-8 levels were positively correlated with recurrent abortion in RSA pregnant women(r=0.426,P＜0.001).Logistic regression test showed that serum IL-8 level 154.74 pg/ml was a risk factor for recurrent abortion in RSA pregnant women(OR=2.969,P＜0.05).ROC curve analysis presented that serum IL-8 levels have certain predictive value for recurrent abortion in RSA pregnant women(AUC=0.737,P=0.001).Conclusion IL-8 may participate in the pathological process of RSA,and the high expression of serum IL-8 plays an important role in the process of recurrent abortion in pregnant women with RSA.Detecting serum IL-8 levels can predict the occurrence of recurrent abortion in pregnant women with RSA.
NETL
NSTL
万方数据
维普
