Influences of weight control in pre-competition training on gut microbiota and its metabolites in wrestlers
Objective To observe the influences of weight control in pre-competition training on the intestinal flora and metabolites of wrestlers.Methods The stool samples of 11 wrestling athletes from Shaanxi Province were collected be-fore and after the pre-competition training.16S rRNA gene sequencing technology was used to detect intestinal flora,and non-targeted metabolomics technology was used to analyze metabolites.Results The weights of wrestlers decreased sig-nificantly after pre-competition training(P＜0.05).In men,the abundance of Roseburia significantly reduced while that of Intestinibacter significantly increased,and the changes were positively correlated with the changes in body weight and skeletal muscle index of limbs.No difference in flora was found in female group.The results of metabolic group showed that the expression of metabolites related to cholesterol metabolism was down-regulated by pre-competition training.Changes in the abundance of Intestinibacter were positively correlated with changes in the abundance of bile acid 7alpha-hydroxy-3-oxo-4-cholestenoate.Conclusion The weight control of wrestlers during pre-competition training had no sig-nificant influence on the overall abundance and diversity of intestinal flora,but there were sex differences in individual mi-crobial abundance.The abundance of an Intestinibacter is associated with changes in body weight,skeletal muscle,and is involved in the regulation of bile acid metabolism.The above research is helpful to further explore the impact of weight control training on athletes'health and competitive performance,and provide a basis for training and nutrition strategy op-timization.
Gut microbiotaMetabolitePre-competition trainingWeight controlWrestlers
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