Preventive effect of Bifidobacterium Triple Viable Bacteria on constipation in patients with mixed hemorrhoids after TST and its influence on intestinal flora
Objective To explore the application value of Bifidobacterium Triple Viable Bacteria(BTVB)in patients with mixed hemorrhoids after selective mucosal anastomosis(TST),so as to guide clinical prevention of postoperative con-stipation.Methods A total of 100 patients with mixed hemorrhoids after TST in our hospital from August,2021 to Febru-ary,2023 were selected as the subjects,and were divided into control group(n=46,receiving Mosapride treatment)and re-search group(n=54,receiving Mosapride combined with BTVB treatment).After two weeks of continuous treatment,the incidence of postoperative constipation,postoperative recovery(time to flatulence,time to defecation and hospitalization days),difficulty in defecation,fecal characteristics,counts of intestinal flora,serum substance P(SP)and vasoactive intest-inal peptide(VIP)levels were statistically compared between the two groups.Results The incidence of constipation in the research group was lower than that in the control group(x2=4.61 7,P=0.032).The time to first flatulence,time to defec-ation and hospitalization days in the research group were shorter than those in the control group respectively(t=1 5.103,13.358,8.463,all P＜0.001).After two weeks of treatment,the difficulty of defecation and the score of fecal characterist-ics in the research group were lower than those in the control group(t=5.221,4.001,all P＜0.001).The counts of Lactoba-cillus and Bifidobacterium in the research group were higher,while those of Enterobacter,Coccidium and Yeast were lower than in the control group respectively(t=4.646,3.688,2.454,4.818,8.681,all P＜0.001).The serum SP level in the research group was higher,and the VIP level was lower than that in the control group respectively(t=3.328,8.999,all P＜0.001).Conclusion Bifidobacterium Triple Viable Bacteria can prevent constipation in patients with mixed hemor-rhoids after TST,and optimize the intestinal flora and the secretion of brain and intestinal peptide hormones.
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