The intestinal flora distribution and its correlation with glucose and lipid metabolism indexes in patients with type 2 diabetes mellitus and coronary heart disease
Objective To explore the relationship between intestinal flora distribution and glucose and lipid metabolism indexes in type 2 diabetes mellitus(T2DM)patients with coronary heart disease(CHD),providing a reference for the treat-ment.Methods Fifty patients with T2DM and CHD treated in our unit from January to December 2021 were selected as the observation group,and 50 healthy individuals who underwent physical examination in our unit during the same period were selected as the control group.The basic data,intestinal flora(Enterobacterium,Enterococcus,Bifidobacterium,Bac-teroides,Lactobacillus)distribution,glucose metabolism indexes[fasting blood glucose(FPG),glycated hemoglobin(HbA1c)],fasting insulin(FINS),and lipid metabolism indexes[triglyceride(TG),total cholesterol(TC),high density lipo-protein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)]were compared between the two groups.The correlation between intestinal flora distribution and glucose and lipid metabolism indexes was analyzed.Results There were no differences in age,sex,body mass index,systolic blood pressure,diastolic blood pressure,disease course,smoking history and hypertension history between the two groups(all P＞0.05).The levels of Enterobacter and Enterococcus in the observation group were higher,while those of Bifidobacterium,Bacteroides and Lactobacillus were lower than those in the control group respectively(all P＜0.05).The FPG,FINS and serum HbA1c in the observation group were higher than those in the control group(all P＜0.05).The serum levels of TC,TG and LDL-C in the observation group were higher,and that of HDL-C was lower than those in the control group,respectively(all P＜0.05).Enterobacterium and Enterococcus were positively correlated with FPG,HbA1c,FINS,TC,TG and LDL-C,and negatively correlated with HDL-C(all P＜0.05).Bifidobacterium,Bacteroides and Lactobacillus were negatively correlated with FPG,HbAlc,FINS,TC,TG and LDL-C,and positively correlated with HDL-C(all P＜0.05).Conclusion In T2DM patients with coronary heart dis-ease,the counts of Enterobacterium and Enterococcus increased,while those of Bifidobacterium,Bacteroides and Lactoba-cillus decreased,and the level of intestinal flora was significantly correlated with the indexes of glucose and lipid metabol-ism.
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