Correlation between gut microbiota and the severity of abdominal Henoch-Sch?nlein purpura nephritis
Objective To explore the correlation between gut microbiota and the severity of abdominal Henoch-Schönlein purpura nephritis(HSPN)in children.Methods A total of 115 children with abdominal type Henoch-Schönlein purpura(HSP)admitted to our hospital from April 2021 to April 2023 were included as the subjects,and grouped into HSP group(69 cases)and HSPN group(46 cases)based on whether they developed nephritis.According to the 24 hour urine protein quantification results,the children with HSPN were divided into a mild HSPN group(29 cases)and a severe HSPN group(17 cases).One hundred and fifteen healthy children who were examined in our hospital were enrolled as the control group.The changes in the count of intestinal microbiota were compared between groups.Results The 24 hour urine pro-tein quantification,blood urea nitrogen(BUN),serum creatinine(SCR),serum uric acid(SUA)and white blood cell(WBC)levels in the control group,HSP group,and HSPN group sequentially increased(P＜0.05).The 24 hour urine pro-tein quantification,BUN,SCR,SUA,red blood cell(RBC)and WBC in the severe HSPN group were higher than those in the mild HSPN group(P＜0.05).The levels of bifidobacteria and lactobacillus in the control group,HSP group,and HSPN group gradually decreased,while those of Escherichia coli and streptococcus gradually increased(P＜0.05).The levels of bifidobacteria and lactobacillus in the severe HSPN group were lower,while those of E.coli and streptococcus were higher than those in the mild HSPN group,respectively(P＜0.05).After treatment,the levels of bifidobacteria and lactobacillus in children with HSPN were lower,and those of E.coli and streptococcus were higher than those before treatment,respect-ively(P＜0.05).Conclusion The more severe the condition of children with abdominal HSPN,the more severe the dis-order of intestinal flora with decreasing beneficial bacteria and increasing pathogenic bacteria.
Abdominal Henoch-Schoenlein purpura nephritisIntestinal microbiotaSeverity of condition
NETL
NSTL
万方数据
