Correlation between gut microbiota and dementia with Lewy body
Objective To explore the composition and correlation of gut microbiota in patients with dementia with Louis body(DLB).Methods Seventeen DLB patients and 21 healthy control patients(HC)recruited from the hospital from January 2021 to August 2023 were selected and divided into DLB group and HC group,respectively.The DLB group was evaluated using the mini-mental state examination(MMSE),activities of daily living(ADL)scale,Parkinson's Compre-hensive Score Part Ⅲ(UPDRS Ⅲ),and the intestinal microbiota composition was compared between the two groups through 16S rRNA sequencing.Spearman correlation analysis was used to evaluate the correlation between microbial com-munity characteristics and the severity of DLB.Results There were no statistically significant differences in gender,age and education duration between the two groups(P＞0.05).However,when comparing DLB group to the HC group,signi-ficant differences were observed in MMSE scores,ADL scores,and UPDRS Ⅲ scores(P＜0.001).In comparison to the HC group,the DLB group exhibited decreased diversity in gut microbiota(P＜0.05),with a decrease in the relative abund-ance of Faecalibacterium and an increase in Escherichia-Shigella,Streptococcus and Ligilactobacillus(P＜0.05).The rel-ative abundance of Faecalibacterium showed a positive correlation with MMSE scores(r=0.405,P＜0.001)and a negative correlation with disease duration and UPDRS Ⅲ scores(r=-0.238,P=0.019).On the other hand,Escherichia-Shigella ex-hibited a positive correlation with disease duration and UPDRS Ⅲ scores(r-0.263,P=0.008)and a negative correlation with MMSE scores and ADL scores(r=-0.290,P=0.003).Conclusion The composition of gut microbiota in DLB pa-tients changed,and the dysbiosis may play a role in the occurrence and development of DLB.
Dementia with Lewy bodyIntestinal brain axisIntestinal microbiota
NETL
NSTL
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