Detection of indicators of cervical secretions and its clinical significance in patients with different levels of cervical squamous intraepithelial lesions
Objective To observe the detection of indicators of cervical secretions in patients with different levels of cer-vical squamous intraepithelial lesions(SIL)and discuss its clinical significance.Methods A total of 164 patients with SIL in our hospital from March 2022 to May 2023 were enrolled.Based on the pathological examination results,the pa-tients were divided into a low-grade SIL(LSIL)group(n=72)and a high grade SIL(HSIL)group(n=92).Additionally,21 cervical cancer patients were included as the cervical cancer group,and 60 healthy women were included as the control group.The positive rates and pH values of vaginal leukocyte esterase(LE),N-neneneba acetyl galactosamine glycosidase(NAG),sialic acid glycosidase(SNA),hydrogen peroxide(H2O2),vaginal trichomonas infection,and positive rates of aer-obic vaginitis(AV)and bacterial vaginosis(BV)in the four groups were observed.The vaginal cleanliness in the four groups was evaluated,and the HPV infection was observed.The degree of cervical lesions and vaginal microenvironment were analyzed using Spearman to observe the correlation with HPV infection.Results The detection rates and pH values of LE,NAG,SNA,and H2O2 in the LSIL group,HSIL group,and cervical cancer group were significantly higher than those in the control group respectively(all P＜0.05).As the degree of cervical lesions deepened,the positive rates and pH values of LE,NAG,SNA,and H2O2 showed an upward trend(all P＜0.05).The LSIL group,HSIL group,and cervical cancer group had significantly higher rates of trichomonas infection and positive rates of AV and BV than the control group(all P＜0.05).As the degree of cervical lesions deepened,the trichomonas infection,and positive rates of AV and BV showed an upward trend(all P＜0.05).The proportion of vaginal cleanliness level Ⅰ to Ⅱ in the LSIL group,HSIL group,and cervical cancer group was lower,while that of level Ⅲ to IV was higher than in the control group respectively(all P＜0.05).As the degree of cervical lesions deepened,vaginal cleanliness became worse(all P＜0.05).The proportions of high-risk HPV infection and total incidences of HPV infection in the LSIL group,HSIL group,and cervical cancer group were higher than those in the control group,respectively(all P＜0.05).As the degree of cervical lesions deepened,the in-cidence of high-risk HPV infection and HPV infection showed an upward trend(all P＜0.05).The degree of cervical le-sions was positively correlated with trichomonas infection,AV,BV,LE,NAG,SNA,H2O2,pH value,vaginal cleanliness,and HPV infection,with statistically significant differences(all P＜0.05).Conclusion The cervical microenvironment of SIL patients is significantly imbalanced,and there is a significant correlation between the degree of cervical lesions and the indicators of secretions.
NETL
NSTL
万方数据
