Interaction between intestinal flora,postbiotics,and the intestinal mucus barrier in colorectal cancer
Microecological imbalance can have an impact on the function of the host intestinal mucus barrier,which can lead to inflammatory diseases and colorectal cancer.The epithelial cells of colon create a protective double mucus layer by producing mucin,which helps shield them from harsh environments and harmful bacteria.The composition of intestinal flora can influence the expression of mucin and the function of intestinal mucus barrier.Furthermore,changes in dietary patterns can also affect the composition of intestinal flora.Modulating the intestinal flora through microbiota therapy,in-cluding fecal microbiota transplantation,has become an important approach to improving the pathological symptoms asso-ciated with microbial dysbiosis.Therefore,adopting a sensible dietary pattern can help regulate the interplay between the intestinal flora,bacterial metabolites(postbiotics),and the host.This regulation can help maintain the composition of intest-inal mucus and the synthesis of mucin,ultimately enhancing the function of intestinal mucus barrier and reducing the risk of inflammatory diseases and colorectal cancer in intestinal tract.
Intestinal floraPostbioticsMucinIntestinal mucus barrierColorectal cancer
NETL
NSTL
万方数据
