肠道菌群、后生元与肠道黏液屏障在结直肠癌中的交互作用
Interaction between intestinal flora,postbiotics,and the intestinal mucus barrier in colorectal cancer
范金清 1李雅茹 2张思琪 2温俊斌 2伦永志2
作者信息
- 1. 莆田学院附属医院检验科,福建莆田 351100;莆田学院药学与医学技术学院医学微生态学福建省高校重点实验室
- 2. 莆田学院药学与医学技术学院医学微生态学福建省高校重点实验室
- 折叠
摘要
微生态失衡会影响宿主肠道黏液屏障功能,从而导致炎症性疾病和结直肠癌的发生.结肠上皮细胞通过分泌黏蛋白形成双层黏液层来保护自己免受恶劣环境和各种病原菌的侵袭.肠道菌群的组成能够影响黏蛋白的表达和肠道黏液屏障的功能,而饮食模式的变化又可以影响肠道菌群的组成.通过菌群疗法(包括粪菌移植)调节肠道菌群已成为改善微生态失调相关病理学表现的重要手段.因此,合理的饮食模式可以调节肠道菌群、细菌代谢物(后生元)与宿主之间的相互作用,并维持肠道黏液的组成和黏蛋白的合成,从而增强肠道黏液屏障的功能,降低肠道炎症性疾病和结直肠癌的风险.
Abstract
Microecological imbalance can have an impact on the function of the host intestinal mucus barrier,which can lead to inflammatory diseases and colorectal cancer.The epithelial cells of colon create a protective double mucus layer by producing mucin,which helps shield them from harsh environments and harmful bacteria.The composition of intestinal flora can influence the expression of mucin and the function of intestinal mucus barrier.Furthermore,changes in dietary patterns can also affect the composition of intestinal flora.Modulating the intestinal flora through microbiota therapy,in-cluding fecal microbiota transplantation,has become an important approach to improving the pathological symptoms asso-ciated with microbial dysbiosis.Therefore,adopting a sensible dietary pattern can help regulate the interplay between the intestinal flora,bacterial metabolites(postbiotics),and the host.This regulation can help maintain the composition of intest-inal mucus and the synthesis of mucin,ultimately enhancing the function of intestinal mucus barrier and reducing the risk of inflammatory diseases and colorectal cancer in intestinal tract.
关键词
肠道菌群/后生元/黏蛋白/肠道黏液屏障/结直肠癌Key words
Intestinal flora/Postbiotics/Mucin/Intestinal mucus barrier/Colorectal cancer引用本文复制引用
基金项目
消化道恶性肿瘤教育部重点实验室(福建医科大学)开放课题基金(FMUGIC-202103)
莆田学院校级科研项目(2021042)
莆田学院大学生创新创业训练计划项目(X202311498018)
出版年
2024
NETL
NSTL
万方数据