基于肠道菌群探讨高脂饮食在慢性便秘中的作用及机制
The role and mechanism of high-fat diet in chronic constipation based on intestinal flora
张琳昆 1张亚峰 2许翠萍2
作者信息
- 1. 山西医科大学,山西太原 030001
- 2. 山西医科大学第一医院消化内科
- 折叠
摘要
慢性便秘是一种患病率高、治疗困难的功能性肠道疾病.许多患者临床治疗效果差,生活质量显著降低.近年来的研究认为慢性便秘的发生发展与肠道菌群失调有关.饮食结构是影响肠道菌群组成的主要因素,已有研究发现高脂饮食可引起肠道菌群失调,进而导致慢性便秘的发生,但具体机制尚未完全阐明.本文从5-羟色胺、短链脂肪酸和慢性肠道炎症等几个方面综述高脂饮食通过影响肠道菌群引起慢性便秘的作用及机制,以期通过精准的饮食干预调节肠道菌群,达到预防和治疗慢性便秘的目的.
Abstract
Chronic constipation is a functional intestinal disease with a high prevalence and difficult to treat.Many pa-tients have poor clinical treatment results and a significantly reduced quality of life.In recent years,the development of chronic constipation is believed to be related to intestinal dysbiosis.Dietary is an important influencing factor of the com-position of intestinal flora.Some studies have found that high-fat diet can cause intestinal dysbiosis,which can lead to the occurrence of chronic constipation,but the specific mechanism has not been fully elucidated.This paper summarizes the ef-fect and mechanism of high-fat diet causing chronic constipation by affecting intestinal flora from several aspects,such as 5-hydroxytryptamine,short-chain fatty acids and chronic intestinal inflammation,in order to achieve the purpose of prevent-ing and treating chronic constipation by regulating intestinal flora through precise dietary intervention.
关键词
慢性便秘/高脂饮食/肠道菌群/5-羟色胺/短链脂肪酸Key words
Chronic constipation/High-fat diet/Intestinal microflora/5-hydroxytryptamine/Short-chain fatty acids引用本文复制引用
出版年
2024
NETL
NSTL
万方数据