The role and mechanism of high-fat diet in chronic constipation based on intestinal flora
Chronic constipation is a functional intestinal disease with a high prevalence and difficult to treat.Many pa-tients have poor clinical treatment results and a significantly reduced quality of life.In recent years,the development of chronic constipation is believed to be related to intestinal dysbiosis.Dietary is an important influencing factor of the com-position of intestinal flora.Some studies have found that high-fat diet can cause intestinal dysbiosis,which can lead to the occurrence of chronic constipation,but the specific mechanism has not been fully elucidated.This paper summarizes the ef-fect and mechanism of high-fat diet causing chronic constipation by affecting intestinal flora from several aspects,such as 5-hydroxytryptamine,short-chain fatty acids and chronic intestinal inflammation,in order to achieve the purpose of prevent-ing and treating chronic constipation by regulating intestinal flora through precise dietary intervention.
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