Distribution of intestinal flora and their correlation with glucose-lipid metabolism and inflammation indexes in patients with T2DM and obesity
Objective To analyze the distribution of intestinal floras and their correlation with glucose-lipid metabolism and inflammation indexes in patients with type 2 diabetes mellitus(T2DM)and obesity,providing a reference for the treat-ment.Methods A total of 120 patients with T2DM and obesity,120 patients with obesity alone and 120 healthy adults in our hospital were enrolled as the observation group,obesity group and control group between June 2020 and June 2022,re-spectively.The counts of intestinal floras(Enterococci,Enterobactesr,Lactobacillissus,Bifidobacteria,Fusobacteria,Bac-teroidertes,Bacteroides),levels of serum glucose-lipid metabolism indexes[glycosylated hemoglobin(HbAlc),fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]and inflammation indexes[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)]were compared among groups.The correlation between the relevant indexes and intestinal floras was analyzed with Pearson analysis.Results The counts of Enterococci and Enterobacters were the highest in observation group,followed by obesity group and control group(all P＜0.05),while the counts of Lactobacillus,Bifidobacteria,Fus-obacteria,Bacteroidertes and Bacteroides were on the contrary(all P＜0.05).The levels of blood glucose,blood lipids(TC,TG,LDL-C)and inflammation indexes were the highest in observation group,followed by obesity group and control group(all P＜0.05),while the HDL-C level was on the contrary(all P＜0.05).The results of Pearson analysis showed that the counts of Enterococci and Enterobacters were positively correlated with blood glucose,blood lipids(TC,TG)and in-flammation indexes,while those of Lactobacillus,Bifidobacteria,Fusobacteria,Bacteroidertes and Bacteroides were neg-atively correlated with them(all P＜0.05).Conclusion In patients with T2DM and obesity,the counts of Enterococci and Enterobacters increased,while those of Lactobacillus,Bifidobacteria,Fusobacteria,Bacteroidertes and Bacteroides de-creased.The changes of intestinal floras are related to glucose-lipid metabolism and inflammatory status.
Type 2 diabetes mellitusObesityIntestinal floraGlucose-lipid metabolismInflammation
NETL
NSTL
万方数据
