The changes of gut microbiota in patients with constipation-predominant irritable bowel syndrome and efficacy of Bifidobacterium Tetravaccine Tablets
Objective To observe the changes of gut microbiota in patients with constipation-Predominant irritable bowel syndrome(IBS-C),and analyze the effect of Bifidobacterium Tetravaccine Tablets(BTTs)intervention.Methods A total of 162 IBS-C patients admitted to our hospital from February 2020 to November 2021 were selected as the subjects,and 113 healthy subjects in the same period were selected as the control group.16S rDNA high-throughput sequencing method was used to detect the composition of gut microbiota and analyze the diversity of gut microbiota of all the subjects.The changes of gut microbiota and constipation-related indicators in patients with IBS-C were analyzed after 8 weeks of inter-vention with BTTs.Results The Ace index(P=0.001),Chao index(P＜0.001),Shannon index(P=0.020)and Sobs in-dex(P＜0.001)of gut microbiota in the observation group were significantly lower than those in the control group.At the phylum level,the abundance of Firmicutes and Proteobacteria in the observation group was significantly higher than that in the control group,while the abundance of Bacteroidetes was significantly lower than that in the control group.After the in-tervention of BTTs,the abundance of Firmicutes and Proteobacteria decreased significantly,while the abundances of Bac-teroidetes increased significantly.The abundance of Lactobacillus and Bifidobacterium in the observation group was signi-ficantly lower than that in the control group.The abundance of Lactobacillus,Bifdobacterium and Faecalibaculum in-creased significantly after the intervention of BTTs.After intervention,the constipation symptom score,gastrointestinal quality of life index(GIQLI)score,Wexner constipation(WC)score and patient assessment of constipation quality of life(PAC-QOL)score of IBS-C patients signifiicantly increased compared with those before intervention,and the frequency of defecation also significantly increased(P＜0.05).Conclusion The gut microbiota of IBS-C patients is obviously dis-ordered.Bifidobacterium Tetravaccine Tablet can regulate the imbalance of gut microbiota to a certain extent,and improve gastrointestinal function and constipation symptoms.
Irritable bowel syndrome with constipationGut microbiotaBifidobacterium Tetravaccine Tablets
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NSTL
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