Changes of upper respiratory tract flora and inflammatory factors in children with bronchial asthma and their relationship with the severity of the disease
Objective To explore the changes of upper respiratory flora and inflammatory factors in children with bron-chial asthma(BA)and analyze the relationship of them with the severity of the illness,so as to provide reference indicators for clinical evaluation of the severity of BA in children.Methods A total of 103 children with BA admitted to the First People's of Zhaoqing City during October 2018 and June 2022 were selected as the observation group,with another 60 healthy children who underwent physical examination in our hospital during the same time period as the control group.The observation group was divided into two subgroups,mild and severe,according to the severity of the disease.The diversity of upper respiratory flora and serum levels of the inflammatory factors C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor(TNF)-α were detected,and the relationship between the above indexes and the severity of the dis-ease was analyzed.Results Compared with the control group,the children in the observation group had significantly higher levels of Simpson's index,serum CRP,IL-6 and TNF-α,and significantly lower levels of Shannon's index(t=52.413,35.293,36.088,34.930,29.248;all P＜0.001).The Simpson's index,serum CRP,IL-6 and TNF-α levels of chil-dren in the severe group were significantly higher,while Shannon's index was significantly lower than those in the mild group respectively(t=11.599,11.898,12.699,11.335,12.309;all P＜0.001).Spearman's correlation analysis showed that the Simpson's index,serum CRP,IL-6,and TNF-α were positively correlated with the severity of the disease(r=0.197,0.228,0.264,0.287;P=0.046,0.020,0.007,0.003),and Shannon's index was negatively correlated with the severity of BA(r=-0.270,P=0.006).The receiver operating characteristic curve(ROC)showed that the areas under the curve(AUC)of respiratory flora diversity,inflammatory factor levels,and the joint detection of the two to predict the severity of BA in children were 0.615,0.658,0.634,0.654,0.668 and 0.863,respectively,and that the joint detection had a higher predictive value for the severity of BA in children.Conclusion The levels of upper respiratory flora diversity and inflammatory factors in children with BA significantly elevated,and as the severity of the disease became higher,the levels changed more significantly,with a certain degree of relevance;joint detection of the two has a high predictive value for the severity of BA in children.
Bronchial asthmaRespiratory floraInflammationSeverity of disease
NETL
NSTL
万方数据
