摘要
目的 探讨复合乳酸菌联合蒙脱石散对慢性腹泻患儿肠道菌群、氧化应激和炎性因子的影响,为该类患者的治疗提供参考.方法 选取2020年6月至2022年8月我院门诊收治的400例慢性腹泻患儿作为研究对象,按照随机数表法分为观察组(予以复合乳酸菌联合蒙脱石散治疗)与对照组(仅予以复合乳酸菌治疗),各200例.对比2组患儿肠道菌群(双歧杆菌、乳杆菌、大肠埃希菌)和应激指标[丙二醛(MDA)、一氧化氮(NO)]、炎性因子[白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)]、胃肠道激素[胃泌素(GAS)、胃动素(MOT)、生长抑素(SSTI)]水平的变化.结果 治疗后,观察组患儿肠道双歧杆菌、乳杆菌数量均高于对照组,而大肠埃希菌数量低于对照组(均P＜0.05);同时观察组患儿MDA、NO、TNF-α、GAS、MOT水平均低于对照组,而IL-10、IFN-γ、SSTI水平均高于对照组(均P＜0.05).结论 复合乳酸菌联合蒙脱石散治疗慢性腹泻的疗效显著,有利于调节患儿肠道菌群以及氧化应激、炎性因子水平.
Abstract
Objective To explore the effects of compound lactic acid bacteria(LAB)combined with Montmorillonite powder on intestinal microecology,oxidative stress and inflammatory factors in children with chronic diarrhea,providing a reference for the treatment.Methods A total of 400 children with chronic diarrhea admitted in our hospital from June,2020 to August,2022 were randomly divided into observation group(given compound LAB combined with Montmorillon-ite powder)and control group(given compound LAB alone),with 200 cases in each group.The intestinal flora(Bifidobac-terium,Lactobacillus,Escherichia coli),stress indicators[malondialdehyde(MDA),nitric oxide(NO)],inflammatory factors[interleukin 10(IL-10),tumor necrosis factor α(TNF-α),interferon-γ(IFN-γ)]and gastrointestinal hormones[gast-rin(GAS),motilin(MOT),somatostatin(SSTI)]were compared between groups.Results After treatment,the counts of Bifidobacterium and Lactobacillus in the observation group were higher,while that of Escherichia coli was lower than those in the control group respectively(all P＜0.05).The levels of MDA,NO,TNF-α,GAS and MOT in the observation group were lower,while those of IL-10,IFN-γ and SSTI were higher than those in the control group respectively(all P＜0.05).Conclusion Compound lactic acid bacteria combined with Montmorillonite powder is effective in treating chronic diarrhea in children,which is beneficial to regulate intestinal microecology,oxidative stress and inflammatory factors.
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