赖氨酸维B12合剂联合西沙比利对功能性消化不良腹痛患儿肠道菌群及胃肠功能的影响
Effects of lysine vitamin B12 mixture combined with Cisapride on intestinal floras and gastrointestinal function in children with functional dyspepsia and abdominal pain
阎婷婷 1聂莹 1杨莹1
作者信息
- 1. 临汾市妇幼保健院儿童医院儿三科,山西 041000
- 折叠
摘要
目的 探讨赖氨酸维B12合剂联合西沙比利对功能性消化不良(FD)腹痛患儿肠道菌群及胃肠功能的影响,以期为临床提供参考.方法 选取2022年5月至2023年6月于本院收治的90例FD伴腹痛患儿,采用简单随机分组将患儿分为单一组(n=45)和联合组(n=45),单一组患儿采用西沙比利治疗,联合组患儿采用赖氨酸维B12合剂联合西沙比利治疗.比较两组患儿的疗效,治疗前后患儿的肠道菌群、胃肠功能和疼痛程度,记录两组患儿治疗期间的不良反应发生情况.结果 联合组患儿治疗的有效率为95.56％,单一组为82.22％,差异有统计学意义(x2=4.050,P＜0.05).治疗后,联合组患儿的乳杆菌和双歧杆菌数量较单一组高,大肠埃希菌数量较单一组低,差异均有统计学意义(r=11.065,17.829,7.985,均P＜0.05).治疗后,联合组患儿的粪便性质分级量表评分较单一组高,克利夫兰便秘评分量表和视觉模拟评分量表评分较单一组低,差异均有统计学意义(t=4.395,4.414,10.302,均P＜0.05).治疗后,联合组患儿的胃动素和胃泌素水平较单一组高,生长抑素水平较单一组低,差异均有统计学意义(t=6.102,10.743,10.908,均P＜0.05).联合组患儿的不良反应发生率为6.67％,单一组为13.33％,差异无统计学意义(x2=0.485,P＞0.05).结论 赖氨酸维B12合剂联合西沙比利治疗FD伴腹痛患儿具有较好的临床疗效且无明显不良反应,可以缓解腹痛,改善肠道菌群和胃肠功能.
Abstract
Objective To observe the effects of lysine-vitamin B12 mixture combined with Cisapride on intestinal flora and gastrointestinal function in children with functional dyspepsia(FD)and abdominal pain.Methods A total of 90 chil-dren with FD and abdominal pain admitted to the hospital were enrolled between May 2022 and June 2023.According to simple random grouping method,they were divided into combination group(n=45,lysine-vitamin B12 mixture combined with Cisapride)and single drug group(n=45,Cisapride).The efficacy,intestinal flora,gastrointestinal function and pain degree were compared between the two groups before and after treatment.The occurrence of adverse reactions during treat-ment was recorded.Results The difference in response rate of treatment between combination group and single drug group was statistically significant(95.56％vs 82.22％,x2=4.050,P＜0.05).After treatment,the counts of Lactobacillus and Bifidobacterium in combination group were higher,while that of Escherichia coli was lower than in single drug group re-spectively(t=1 1.065,t=17.829,t=7.985,all P＜0.05).After treatment,the score of stool nature grading(Bristol)scale in combination group was higher,and those of Cleveland Constipation Scale and visual analogue scale were lower than those in single drug group(t=4.395,t=4.414,t=10.302,all P＜0.05).After treatment,the levels of motilin and gastrin in combin-ation group were higher,while that of somatostatin was lower than in single drug group respectively(t=6.102,t=10.743,t=10.908,all P＜0.05).The difference in incidence of adverse reactions between combination group and single drug group was not statistically significant(6.67％vs 13.33％,x2=0.485,P＞0.05).Conclusion Clinical efficacy of lysine-vitamin B12 mixture combined with Cisapride is good in children with FD and abdominal pain,with no obvious adverse reactions,which can relieve abdominal pain,improve intestinal flora and gastrointestinal function.
关键词
赖氨酸维B12合剂/西沙比利/功能性消化不良腹痛/肠道菌群/胃肠功能Key words
Lysine vitamin B12 mixture/Cisapride/Functional dyspepsia and abdominal pain/Intestinal flora/Gastrointest-inal function引用本文复制引用
出版年
2024
NETL
NSTL
万方数据