Effects of lysine vitamin B12 mixture combined with Cisapride on intestinal floras and gastrointestinal function in children with functional dyspepsia and abdominal pain
Objective To observe the effects of lysine-vitamin B12 mixture combined with Cisapride on intestinal flora and gastrointestinal function in children with functional dyspepsia(FD)and abdominal pain.Methods A total of 90 chil-dren with FD and abdominal pain admitted to the hospital were enrolled between May 2022 and June 2023.According to simple random grouping method,they were divided into combination group(n=45,lysine-vitamin B12 mixture combined with Cisapride)and single drug group(n=45,Cisapride).The efficacy,intestinal flora,gastrointestinal function and pain degree were compared between the two groups before and after treatment.The occurrence of adverse reactions during treat-ment was recorded.Results The difference in response rate of treatment between combination group and single drug group was statistically significant(95.56％vs 82.22％,x2=4.050,P＜0.05).After treatment,the counts of Lactobacillus and Bifidobacterium in combination group were higher,while that of Escherichia coli was lower than in single drug group re-spectively(t=1 1.065,t=17.829,t=7.985,all P＜0.05).After treatment,the score of stool nature grading(Bristol)scale in combination group was higher,and those of Cleveland Constipation Scale and visual analogue scale were lower than those in single drug group(t=4.395,t=4.414,t=10.302,all P＜0.05).After treatment,the levels of motilin and gastrin in combin-ation group were higher,while that of somatostatin was lower than in single drug group respectively(t=6.102,t=10.743,t=10.908,all P＜0.05).The difference in incidence of adverse reactions between combination group and single drug group was not statistically significant(6.67％vs 13.33％,x2=0.485,P＞0.05).Conclusion Clinical efficacy of lysine-vitamin B12 mixture combined with Cisapride is good in children with FD and abdominal pain,with no obvious adverse reactions,which can relieve abdominal pain,improve intestinal flora and gastrointestinal function.
Lysine vitamin B12 mixtureCisaprideFunctional dyspepsia and abdominal painIntestinal floraGastrointest-inal function
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