The relationship of intestinal flora with inflammatory response and vascular endothelial function
Objective To analyze the relationship of intestinal flora with inflammatory response and vascular endothelial function in patients with preeclampsia,providing a reference for the treatment.Methods Seventy patients with pree-clampsia admitted to our unit from February 2021 to March 2023 were selected as the case group,and 70 healthy pregnant women who underwent antenatal examination in our unit during the same period were selected as the control group.Serum levels of inflammatory factors[C-reactive protein(CRP),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)]and vascular endothelial function related factors[vascular endothelial growth factor(VEGF),vascular endothelin(ET),nitric oxide(NO),and soluble endoglin(sEng)]were detected using ELISA.The relationship of intestinal flora with inflammatory response and vascular endothelial function were analyzed with Pearson analysis.Results There were no significant differences in age,pre-pregnancy BMI,low density lipoprotein cholesterol,high density lipoprotein cholesterol,gestational age,menstrual status,number of pregnancies,gestational diabetes,abortion history,smoking history and drink-ing history between the two groups(all P＞0.05).The counts of E.coli and Enterococcus in case group were higher,while those of Bifidobacterium and Lactobacillus were lower than those in control group,respectively(all P＜0.05).The serum levels of CRP,IL-6,TNF-α and IL-8 in case group were higher than those in control group(all P＜0.05).Serum levels of ET and sEng in case group were lower,while those of NO and VEGF were higher than those in control group,respectively(all P＜0.05).Intestinal Escherichia coli and Enterococcus counts were positively correlated with serum CRP,IL-6,TNF-α,IL-8,ET and sEng,and negatively correlated with serum NO and VEGF(all P＜0.05).Intestinal Bifidobacterium and Lactobacillus were negatively correlated with serum CRP,IL-6,TNF-α,IL-8,ET and sEng,and positively correlated with serum NO and VEGF(all P＜0.05).Conclusion In preeclampsia patients,intestinal flora was disturbed,inflammatory re-sponse indexes increased,and vascular endothelial function was damaged.Intestinal flora changes were significantly cor-related with inflammatory response and vascular endothelial function.
PreeclampsiaIntestinal floraInflammatory responseVascular endothelial function
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