Traditional Chinese medicine alleviates depression based on immune inflammation and intestinal flora metabolism
Depression is one of the most common mental diseases with continuous and long-term depression as the main clinical features.The change in intestinal flora can lead to intestinal inflammation,and then affects inflammation in peri-pheral and central nervous system.Modern studies have shown that the occurrence and development of depression are closely related to the change of intestinal flora,which has become a key target for alleviating depression.To a certain ex-tent,traditional Chinese medicine(TCM)can regulate intestinal flora and its metabolites,which repairs the intestinal barri-er and reduces inflammation level throughout the whole body to alleviate depression.With intestinal flora as an entry point,by analyzing the relationship of intestinal flora and immune inflammation with the occurrence and development of depres-sion,as well as the researches on TCM in alleviating depression and regulating intestinal flora,this article summarizes the effects and mechanisms of TCM in reducing inflammation and alleviating depression by regulating intestinal flora,in order to provide new ideas for alleviating depression with TCM and the drug development.
Immune inflammationIntestinal flora metabolismDepressionTraditional Chinese medicine
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NSTL
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