Characteristics of cervical HPV16 and HPV52 single subtype infections based on comparison of vaginal microbiome
Objective To compare and analyze the characteristics of vaginal microecology of cervical human papillo-mavirus(HPV)16 and 52 single subtype infections,and explore the clinical significance of vaginal microbiome differ-ences between HPV16 and 52 single subtype positive patients.Methods A total of 165 cases each of HPV16,HPV52 and HPV-negative subjects were included;all the HPV16 and HPV52 cases were single subtype infections,and the HPV-negat-ive group was used as a blank control group.There was no statistical difference in the general data among the three groups(P＜0.05).HPV typing,liquid-based thin-layer cytology(TCT),and vaginal microecology were detected in all three groups,and the relevant indexes of vaginal microecology(pH,hydrogen peroxide,sialidase,leukocyte esterase enzyme,glucuronidase,acetylglucosaminidase,leukocyte,bacilli,coccus,clue cells,trichomoniasis,cleanliness)and TCT were compared and analyzed.Results(1)The intravaginal pH value was significantly higher in the HPV16 group(5.01±0.31)than in the HPV52(4.71±0.42)group(F=56.26,P＜0.05),and significantly abnormal(F=47.10,P＜0.05)compared to that in the blank control group(4.68±0.43),while there was no significant difference in intravaginal pH value between HPV52 group and the control group(F=0.12,P＞0.05).(2)Compared with HPV52 group and blank control group,the number of abnormal vaginal leukocyte esterase,vaginal microecology,TCT,pH＞4.5 abnormalities in HPV16 group and blank con-trol group significantly increased(all P＜0.05),but the number of vaginal leukocyte esterase and pH＞4.5 in HPV52 group did not increased significantly compared with the blank control group(all P＞0.05).Compared with the HPV52 group,there were no significant differences in vaginal hydrogen peroxide,glucuronidase,acetylglucosaminidase,cleanliness,leukocytes and bar bacteria in HPV16 group(all P＞0.05),but both groups were significantly abnormal compared with the blank control group(all P＜0.05).There were no significant differences in vaginal sialidase,coccus,lead cells and trich-omoniasis among the three groups(all P＞0.05).Conclusion Both HPV16 and HPV52 patients have vaginal microecolo-gical imbalance.HPV16 patients are more likely to have microbiosis and cervical intraepithelial lesions than patients with HPV52 infection,which may be related to the higher vaginal pH.Adjusting pH may be a direction for the treatment of high-risk HPV16 patients,but it may not be applicable for HPV52,and new ideas need to be found for the treatment of HPV52.
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