Effects of GBS infection in reproductive tract on vaginal microecological environment and immune factors in women in late pregnancy
Objective To explore the effects of group B Streptococcus(GBS)infection in reproductive tract on vaginal microecological environment and immune factors in late pregnancy.Methods A total of 76 women with GBS and 76 wo-men without GBS during late pregnancy in the hospital were enrolled as GBS positive group and control group between Ju-ly 2021 and July 2022,respectively.The vaginal microecology,serum immune inflammatory factors(IL-1β,IL-6)and pregnancy outcomes were compared between the two groups.According to evaluation results of vaginal microecology,wo-men in GBS positive group were divided into disordered group(n=56)and normal group(n=20),and pregnancy outcomes in the two groups were compared.Results There were significant differences in vaginal pH,incidence of bacterial vagin-osis(BV)and vulvovaginal candidiasis(VVC),density and diversity of vaginal flora,and the incidence of microecological disorder between the two groups(x2=8.550,5.842,5.156,4.682,5.339,14.341,all P＜0.05),but there was no significant difference in the incidence of trichomoniasis vaginitis(TV)or vaginal cleanliness(x2=0.541,1.685,all P＞0.05).The levels of serum IL-1β and IL-6 in GBS positive group were significantly higher than those in control group(t=16.711,19.388,all P＜0.05).The incidence rates of premature delivery,puerperal infection,fetal distress and pathological jaun-dice in GBS positive group were significantly higher than those in control group(x2=5.365,10.059,7.938,5.787,all P＜0.05),but there were no significant differences in the incidences of premature rupture of membranes,postpartum hem-orrhage,neonatal asphyxia and neonatal pneumonia between the two groups(x2=1.849,0.882,2.027,2.027,all P＞0.05).The incidence rates of premature rupture of membranes and fetal distress in disordered group were significantly higher than those in normal group(x2=4.113,4.113,all P＜0.05),but there were no significant differences in the incidences of prema-ture delivery,puerperal infection,postpartum hemorrhage,neonatal asphyxia,pathological jaundice and neonatal pneumo-nia between the two groups(x2=2.805,1.281,0.384,0.734,0.880/0.734,all P＞0.05).Conclusion GBS infection will in-crease the incidence of vaginal microecology and immune inflammatory factors disorder,and the risk of adverse preg-nancy outcomes in women in late pregnancy.
Group B StreptococcusInfectionLate pregnancyVaginal microecologyImmune inflammatory factor
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