Role of traditional Chinese medicine in triple-negative breast in terms of gut microbiota and tryptophan metabolism:research progress
Triple-negative breast cancer(TNBC)is a subtype of breast cancer with strong immunogenicity.Due to lack of effective therapeutic targets,TNBC is still a refractory type of breast cancer.More and more studies have shown that gut microbiota can influence the occurrence and development of TNBC,and the efficacy of immunotherapy by intervening the tryptophan metabolism of host or microorganisms and reshaping the tumor immune microenvironment.Traditional Chinese medicine(TCM)has been proved to be effective in promoting cell apoptosis,regulating intestinal homeostasis and inhibit-ing inflammatory responses in TNBC in previous studies.However,the mechanisms of TCM intervening gut microbiota and its metabolites and TNBC remain unclear.Therefore,on the basis of basic TCM theory of syndrome differentiation of breast cancer and in the perspective of gut microbiota and tryptophan metabolisms,this article reviewed previous literat-ures,summarized the intervening effect of TCM on gut microbiota and its metabolites,and explored its anti-tumor mechan-isms,hoping to provide new ideas and methods for the treatment of TNBC with integrated TCM and western medicine.
Traditional Chinese medicineGut microbiotaTryptophan metabolismTumor microenvironmentTriple-negative breast cancerImmunotherapy
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