首页|枯草芽孢杆菌纳豆亚种后生元的健康促进作用

枯草芽孢杆菌纳豆亚种后生元的健康促进作用

Health-promoting effects of postbiotic Bacillus subtilis subsp.natto

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枯草芽孢杆菌纳豆亚种是一种食用历史悠久的益生菌,其安全性和健康促进作用已在人群和临床应用上得到很好的证明.特殊的培养、灭活及膜过滤等技术可以利用枯草芽孢杆菌纳豆亚种发酵产生多种后生元成分,如菌体壁、胞外多糖、纳豆激酶、维生素K2和γ-多聚谷氨酸等,这些后生元成分可赋予枯草芽孢杆菌纳豆亚种益生菌潜力.枯草芽孢杆菌纳豆亚种后生元具有重要的健康促进功能,如整肠通便、促进消化、预防和溶解血栓、降血压、促进骨骼钙吸收、降尿酸及抑菌消炎等.本文从后生元的定义出发,探讨枯草芽孢杆菌纳豆亚种后生元的制备方法、功能成分及可能的健康促进作用.
Bacillus subtilis subsp.natto is a probiotic with a long history of consumption,and its safety and health promot-ing effects have been well proven in both human and clinical trials.Special cultivation and membrane filtration techniques can be used to produce a new type of postbiotic using Bacillus subtilis subsp.natto which contains various unique postbiot-ic components,such as bacterial wall,extracellular polysaccharides,nattokinase,vitamin K2,γ-polyglutamic acid and other epigenetic components.These postbiotic components can endow Bacillus subtilis subsp.natto the potential of probiotics with much more unique health promoting functions,such as regulating bowel movements and promoting digestion,pre-venting and dissolving blood clots,lowering blood pressure,promoting bone calcium absorption,reducing uric acid and in-hibiting bacteria and inflammation.This article discusses the definition,preparation methods,functional components and health promoting effects of the postbiotic Bacillus subtilis subsp.natto.

ProbioticsPostbioticsBacillus subtilis subsp.nattoNattokinaseVitamin K2γ-polyglutamic acid

周志谟、刘美汛、贾雯、吴思谋、陈杰鹏、李明、沈曦、程如越、何方

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四川大学华西公共卫生学院/四川大学华西第四医院,四川成都 610041

广东双骏生物科技有限公司

大连医科大学微生态学教研室

益生菌 后生元 枯草芽孢杆菌纳豆亚种 纳豆激酶 维生素K2 γ-多聚谷氨酸

黑龙江省"揭榜挂帅"科技攻关计划黑龙江省"揭榜挂帅"科技攻关计划河北省自然科学基金生物农业联合基金重点项目四川省博士后科研特别资助项目

2021ZXJ03B01-22021ZXJ03B05C2022106016TB2022046

2024

10.13381/j.cnki.cjm.202403020

中国微生态学杂志
中华预防医学会 大连医科大学

中国微生态学杂志

CSTPCD北大核心
影响因子：1.115
ISSN：1005-376X
年,卷(期)：2024.36(3)
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