Influence of gestational diabetes mellitus on intestinal microbiota in female mice
Objective To observe the influences of gestational diabetes mellitus(GDM)on intestinal microecology in fe-male mice.Methods The influences of GDM on intestinal microecology in female mice were analyzed using 16S rRNA gene high-throughput sequencing technology.Results After GDM modeling,the intestinal microbiota of female mice changed significantly,showing that the species diversity of intestinal microbiota increased significantly,the proportion of Firmicutes and Bacteroidetes decreased significantly,and the relative abundance of Lactobacillus and Streptococcus de-creased.The abundance of various opportunistic pathogens such as Dubosiella,Lachnospiraceae_NK4A136_group and Al-lobaculum increased.Conclusion GDM can lead to the imbalance of intestinal microecology and increase the metabolic burden of blood sugar in women,which requires timely monitoring and effective intervention measures.
NETL
NSTL
万方数据
