Effects of Bifidobacterium on gut microbiota,gastrointestinal mucosal barrier function and immune function in patients with acute exacerbation of chronic obstructive pulmonary disease
Objective To explore the impacts of Bifidobacterium on gut microbiota,gastrointestinal mucosal barrier function and immune function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD),providing a reference for the treatment.Methods A total of 166 AECOPD patients admitted to our hospital from May 2021 to May 2023 were enrolled and randomly divided into a treatment group(83 cases)and a control group(83 cases).Both groups received conventional treatment,while the treatment group was additionally given Bifidobacterium.General information of the patients,including age,gender,course of disease and body mass index(BMI),were collected.The gut microbiota,gastrointestinal mucosal barrier function,and immune function of the patients were detected and compared between groups.Results The treatment group had higher total clinical efficiency rate(95.18％vs 85.54％)and lower in-cidence of adverse reactions(6.02％vs 4.82％)than control group(all P＜0.05).There were no statistically obvious differ-ences in the level of gut microbiota,gastrointestinal mucosal barrier function,and immune function between the two groups before treatment(all P＞0.05).After treatment,the counts of intestinal Lactobacillus and Bifidobacterium were higher,while those of Enterobacterium and Enterococcus were lower than before treatment;the levels of diamine oxidase and D-lactate were lower,those of CD3+ cells and CD4+cells were higher,and that of CD8+cells was lower than before treatment.The improvements of intestinal microbiota,gastrointestinal mucosal barrier function and immune indicators in the treat-ment group were better than those in the control group(all P＜0.05).Conclusion Bifidobacterium can obviously im-prove the intestinal microbiota,gastrointestinal mucosal barrier function,and immune function of AECOPD patients,with good safety,and is worthy of clinical promotion.
BifidobacteriumAcute exacerbation of chronic obstructive pulmonary diseaseIntestinal microbiotaGastrointestinal mucosal barrier functionImmune function
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