摘要
目的 探究低体质量新生儿血浆氨基酸代谢谱和肠道菌群变化及其与临床结局的关系,为该类患儿的治疗提供参考.方法 选取2015年1月至2022年12月石家庄市第四医院收治的150例低体质量新生儿作为研究对象,根据临床结局分为结局良好组(117例)与结局不良组(33例),比较两组患儿血浆氨基酸水平和肠道菌群数量.结果 结局不良组患儿死亡3例、败血症5例、贫血5例、支气管肺发育不良9例、视网膜病变6例、先天性心脏病3例、高胆红素血症1例、呼吸窘迫综合征1例.结局不良组患儿出生体质量[(1 368.56±150.73)g]低于结局良好组[(1 563.78±184.95)g],差异有统计学意义(t=5.561,P＜0.05).结局不良组患儿血浆精氨酸、瓜氨酸、半胱氨酸、苏氨酸水平均高于结局良好组(均P＜0.05),而天冬氨酸、谷氨酸、甘氨酸、亮氨酸、缬氨酸水平均低于结局良好组(均P＜0.05).结局不良组新生儿粪便中双歧杆菌、乳杆菌数量均低于结局良好组(均P＜0.05).结论 低体质量新生儿血浆氨基酸代谢水平和肠道菌群与临床不良结局有一定的关系.
Abstract
Objective To explore the plasma amino acid metabolism profile and intestinal microbiota of low birth weight newborns and their relationship with clinical outcomes,providing a reference for the treatment.Methods A total of 150 low weight newborns admitted to Shijiazhuang Fourth Hospital from January 2015 to December 2022 were enrolled and di-vided into a good outcomes group(117 cases)and a bad outcomes group(33 cases)based on their clinical outcomes.The plasma amino acid level and gut microbiota counts were compared between the two groups.Results In the bad outcomes group,there were 3 cases of death,5 cases of sepsis,5 cases of anemia,9 cases of bronchopulmonary dysplasia,6 cases of retinopathy,3 cases of congenital heart disease,1 case of hyperbilirubinemia,and 1 case of respiratory distress syndrome.The birth weight in the bad outcomes group[(1 368.56±150.73)g]was lower than that in the good outcomes group[(1 563.78± 184.95)g](t=5.561,P＜0.05).The levels of arginine,citrulline,cysteine and threonine in infants with bad outcomes were higher(all P＜0.05),while the levels of aspartic acid,glutamic acid,glycine,leucine and valine were lower than those in the good outcomes group,respectively(all P＜0.05).The levels of Bifidobacteria and Lactobacillus in the feces of new-borns with bad outcomes were lower than those in the good outcomes group(all P＜0.05).Conclusion There is a certain relationship between plasma amino acid metabolism levels and intestinal microbiota in low birth weight newborns with bad outcomes.
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