Plasma amino acid metabolism profile and intestinal microbiota in low birth weight newborns and their relationship with clinical outcomes
Objective To explore the plasma amino acid metabolism profile and intestinal microbiota of low birth weight newborns and their relationship with clinical outcomes,providing a reference for the treatment.Methods A total of 150 low weight newborns admitted to Shijiazhuang Fourth Hospital from January 2015 to December 2022 were enrolled and di-vided into a good outcomes group(117 cases)and a bad outcomes group(33 cases)based on their clinical outcomes.The plasma amino acid level and gut microbiota counts were compared between the two groups.Results In the bad outcomes group,there were 3 cases of death,5 cases of sepsis,5 cases of anemia,9 cases of bronchopulmonary dysplasia,6 cases of retinopathy,3 cases of congenital heart disease,1 case of hyperbilirubinemia,and 1 case of respiratory distress syndrome.The birth weight in the bad outcomes group[(1 368.56±150.73)g]was lower than that in the good outcomes group[(1 563.78± 184.95)g](t=5.561,P＜0.05).The levels of arginine,citrulline,cysteine and threonine in infants with bad outcomes were higher(all P＜0.05),while the levels of aspartic acid,glutamic acid,glycine,leucine and valine were lower than those in the good outcomes group,respectively(all P＜0.05).The levels of Bifidobacteria and Lactobacillus in the feces of new-borns with bad outcomes were lower than those in the good outcomes group(all P＜0.05).Conclusion There is a certain relationship between plasma amino acid metabolism levels and intestinal microbiota in low birth weight newborns with bad outcomes.
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