Relationship of gestational diabetes mellitus glycolipid metabolism changes with neonatal meconium microbiota and immune function
Objective To explore the relationship of gestational diabetes mellitus(GDM)glycolipid metabolism changes with neonatal meconium microbiota and immune function.Methods Eighty-four GDM patients who underwent prenatal examination and delivery in our hospital from June 2020 to June 2023 were selected as the GDM group,with another 84 healthy pregnant women who underwent prenatal examination and delivery in our hospital during the same period selected as the control group.The glycolipid metabolism indicators,richness,evenness and distribution of neonatal meconium mi-crobiota,and immune function indicators were compared between the two groups.Pearson correlation analysis was used to analyze the correlation between GDM glycolipid metabolism indexes and neonatal meconium microbiota and immune function indicators.Results Compared with the control group,the levels of fasting blood glucose(FBG),2 h postmeal blood glucose(2 h PBG),glycated hemoglobin(HbAlc),total cholesterol(TC),triglyceride(TG)and low density lipopro-tein cholesterol(LDL-C)in GDM group significantly increased(P＜0.001),while the level of high density lipoprotein cho-lesterol(HDL-C)significantly decreased(P＜0.001);the relative abundance of Firmicutes,Chao1,Observed species,Shannon and Simpson indexes significantly decreased(P＜0.001),while the relative abundance of Proteobacteria signific-antly increased(P＜0.001);the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM),ratio of CD3+T lymphocytes and CD4+T lymphocytes,ratio of CD4+/CD8+decreased,while the ratio of CD8+T lymphocytes increased(P＜0.001).In GDM group,the glucose and lipid metabolism indexes were correlated with fetal stool floral indexes and immune function indexes(P＜0.05).There was a correlation between fetal stool flora and immune function(P＜0.001).Conclusion Glucolipid metabolism disorders in GDM patients may affect the immune function and intestinal flora of newborns,and the intestinal flora of newborns may affect the immune function of newborns.
Gestational diabetes mellitusGlycolipid metabolismNeonateMeconium microbiotaImmune function
NETL
NSTL
万方数据
