Interaction and significance of biofilms of Gardnerella and Lactobacillus in vagina
Lactobacillus is generally the dominant bacteria in the vagina of healthy women,where forms the bacteria biofilm.It maintains the balance in the vagina through metabolic and inflammatory mechanisms and so on,maintains the acidic environment in the vagina,and fights against pathogen invasion and colonization.Bacterial vaginosis is caused when pathogens such as Gardnerella disrupt the balance of the microbiota in the vagina.Gardnerella forms biofilm in the va-gina,which enhances its drug resistance and increases the recurrence probability,and results in refractory bacterial vaginos-is.This article reviews the impacts of biofilm formation of Lactobacillus and Gardnerella on vaginal microenvironment,discusses the mechanism of the interaction between their biofilms,further excavates the influence of pathogen biofilm on HPV infection,and provides new strategies for the treatment of infections caused by clinical pathogen biofilm.
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