Progress in research on the relationship between intestinal microecology imbalance and impaired glucose tolerance
Intestinal microecosystem is the largest and most complex microecosystem in the human body,which consists of symbiotic flora and their living environment.Microorganisms provide a variety of biochemical cues for patients with im-paired glucose tolerance(IGT)and participate in a variety of physiological processes.The intestinal microecosystem inter-feres with glucoregulatory mechanisms and insulin sensitivity through a variety of pathways including altered short-chain fatty acid production,lipopolysaccharide-mediated inflammatory responses and bile acid signalling.As therapeutic strategies targeting intestinal microecology continue to be introduced,various therapies represented by exercise,microeco-logical preparations,dietary fibre,dipeptidyl peptidase Ⅳ inhibitors and traditional Chinese medicine have been applied and promoted in clinical practice.This article reviews the relevant research progress and results.Predictably,intestinal mi-croecology as an emerging area of research,is expected to be another key to controlling the onset and development of IGT and delaying the progressive exacerbation of type 2 diabetes.
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