Intestinal microecosystem is the largest and most complex microecosystem in the human body,which consists of symbiotic flora and their living environment.Microorganisms provide a variety of biochemical cues for patients with im-paired glucose tolerance(IGT)and participate in a variety of physiological processes.The intestinal microecosystem inter-feres with glucoregulatory mechanisms and insulin sensitivity through a variety of pathways including altered short-chain fatty acid production,lipopolysaccharide-mediated inflammatory responses and bile acid signalling.As therapeutic strategies targeting intestinal microecology continue to be introduced,various therapies represented by exercise,microeco-logical preparations,dietary fibre,dipeptidyl peptidase Ⅳ inhibitors and traditional Chinese medicine have been applied and promoted in clinical practice.This article reviews the relevant research progress and results.Predictably,intestinal mi-croecology as an emerging area of research,is expected to be another key to controlling the onset and development of IGT and delaying the progressive exacerbation of type 2 diabetes.
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