Current overviews in the efficacy and toxicity of gut microbiota in regulating tumor chemotherapy
Gut microbiota regulates host responses to chemotherapeutic drugs mainly by promoting drug efficacy and re-ducing toxic reactions.In other words,the effect and toxicity of chemotherapy can be improved and reduced by targeting gut microbiota.Therefore,gut microbiota is critical for the development of clinically individualized cancer treatment strategies.This view is based on the results of numerous clinical,animal,and in vitro studies,which shows that gut micro-biota is closely related to the pharmacological effects of not only chemotherapy but also tumor targeted immunotherapy.In this review,we summarized the significance of pharmaco-microbiology in cancer chemotherapy,and summarized the measures to increase the efficacy and reduce toxic reactions by improving the microbiota in clinical practice,in order to provide some references for the development of reasonable clinical drug regimen.
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