目的 应用CiteSpace软件分析皮肤病学领域肠道菌群的研究热点与前沿。方法 检索中国知网、万方、维普及Web of Science数据库中皮肤病学领域肠道菌群相关研究。应用CiteSpace 6。1。R6软件对纳入文献的发文国家、机构、学科及本领域的研究热点和前沿方向进行汇总分析。结果 纳入文献共529篇，其中中文文献302篇，英文文献227篇。纳入文献发文量呈逐年上升趋势。中国发文量为世界首位，但研究较为分散，机构间和研究者间缺少合作。该领域中寻常痤疮、斑秃、银屑病仍为当前研究热点;研究方向以肠道菌群组成分析、代谢产物分析及临床疗效观察为主。结论 本领域文献量仍较少，但发文量处于稳定增长水平，对于炎症性皮肤病的治疗和机制探讨为本领域研究热点，机制研究以菌群构成和代谢途径探讨为主。本领域对不同皮肤病的肠道菌群核心菌群检测尚处于起步阶段，未来应进一步探索不同皮肤病的核心菌群并探究其差异以期进一步探明脑-肠-皮肤轴机制。中医药相关研究干预方式多样，已取得一定成果，但多发表于国内期刊中，相关成果尚未走向国际。
Research trends of gut microbiota in dermatology:bibliometrics analysis based on CiteSpace
Objective To analyze the trends and hot spots of research on intestinal flora in dermatology and venereology by using CiteSpace software.Methods Related studies on intestinal flora in dermatology were retrieved from CNKI,WanFang,VIP and Web of Science databases.CiteSpace 6.1.R6 software was used to conduct statistical analysis on the in-cluded publications.Results A total of 529 articles were included,including 302 in Chinese and 227 in English.The number of publications in the included literatures showed an increasing trend year by year.China ranked first in the world in terms of publication volume,but the research was relatively scattered,and there was a lack of cooperation between insti-tutions and researchers.Acne vulgaris,alopecia areata and psoriasis were the current research frontiers in this field and the research mainly focused on the analysis of intestinal floral composition,metabolite analysis and clinical efficacy observa-tion.Conclusion The amount of literature in this field is still small,but the number of published papers is in a stable growth status.The treatment and mechanism of inflammatory skin disease is the latest frontier in this field,and the mech-anism research mainly focuses on the composition of flora and metabolic pathways.The detection of the core microbiota of intestinal flora in different skin diseases in this field is still in its infancy.More effort should be made to explore the core microbiota of different skin diseases and their differences in order to further explore the brain-gut-skin axis mechanism.Traditional Chinese medicine related research is mostly published in domestic journals,and the relevant results have not yet been published internationally.
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