Effect of micro-ecological preparation assisted endoscopic high-frequency electrocoagulation and electroresection on colon polyps and its influence on intestinal flora and serum inflammatory factors
Objective To observe the effect of micro-ecological preparation assisted endoscopic high-frequency electro-coagulation and electroresection in the treatment of colon polyps,providing a reference for the treatment.Methods A total of 368 patients with colonic polyps treated in our hospital from Jan.2019 to Dec.2022 were selected as the research object.The selected patients were randomly divided into surgery group and combination group,with 184 cases in each group.The patients in the surgery group were treated by endoscopic high frequency electrocoagulation and electro-tomy,while those in the combination group were additionally given micro-ecological preparation(Compound Lactobacil-lus acidophilus Tablets)as adjuvant therapy.Perioperative indexes,intestinal mucosal healing four weeks after surgery,in-testinal flora changes before and three months after surgery,and serum inflammatory factor levels[(interleukin-6(IL-6),tu-mor necrosis factor-α(TNF-α)]before and three months after surgery in the two groups were evaluated,and the recurrence rates at three months and six months after surgery were analyzed.Results There were no statistically significant differ-ences in the perioperative indicators between the two groups(all P＞0.05).The repair of intestinal mucosa in the combina-tion group was better than that in the surgery group(P＜0.05).Three months after operation,the counts of Bifidobacterium and Lactobacillus in the combination group were higher,while that of Escherichia coli was lower than those in the surgery group respectively,and the serum IL-6 and TNF-α were lower than those in the surgery group respectively(all P＜0.05);the recurrence rate(0.00％,2.72％)in the combination group was lower than that in the surgery group(3.80％,11.41％)at three and six months after operation,respectively(all P＜0.05).Conclusion Microecological preparation assisted endo-scopic high-frequency electrocoagulation and electroresection has positive effect in the treatment of colon polyps,which can correct intestinal flora disturbance,promote intestinal mucosal repair,reduce inflammation and help reduce the recur-rence rate.
Endoscopic high-frequency electrocoagulation and electroresectionMicroecological preparationsColon polypsIntestinal floraSerum inflammatory factor
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