Correlation between vaginal microecology and HPV clearance in high-risk human papillomavirus infection patients
Objective To explore the relationship between female vaginal microecology and HPV clearance in patients with high-risk human papillomavirus(HR-HPV)infection,and provide a new idea for clinical prevention and treatment of cervical cancer.Methods Female patients with genital tract infections who were admitted to our hospital from May 2020 to June 2022 were selected as the subjects.Patients information,vaginal secretions and HPV nucleic acid test specimens were collected,and vaginal microecological examination was performed.All the HR-HPV patients were followed up for 1.5 years and genital HPV typing every 6 months,and the leucorrhea routine was reviewed every 3 months.Binary Logist-ic regression was used to analyze the relationship between HR-HPV clearance and vaginal microecology.Results The results of HPV nucleic acid detection and typing showed that the numbers of patients with HPV 16,52 and 58 infection ranked among the top three infections,accounting for 39 cases(27.46％),28 cases(19.72％),32 cases(22.54％),respect-ively.23 patients(7.37％)were diagnosed with trichomoniasis vaginosis(TV),132(42.31％)with vulvovaginal candida disease(VVC),and 157(50.32％)with bacterial vaginosis(BV).Univariate analysis showed that TV and VVC were not risk factors for HR-HPV infection(x2=1.988,P=0.159;x2=1.765,P=0.184);BV was a risk factor for HR-HPV infection(x2=4.200,P=0.040).Among 110 HR-HPV-positive patients,57 ones had improved vaginal microecology,of whom 41(61.19％)had negative HPV nucleic acid test results.Vaginal microecology improvement was not seen in 43 patients,but HPV nucleic acid test results of 15(34.88％)patients among them turned negative,indicating that the improvement of va-ginal microecology may be an influencing factor of HR-HPV clearance rate(x2=7.254,P=0.007).Binary Logistic regres-sion analysis showed that vaginal microecology improvement was a protective factor for HR-HPV clearance(negative)(OR=0.340,95％CI:0.153-0.754,P=0.008).Conclusion The improvement of vaginal microecology can significantly increase the HR-HPV clearance rate and is a protective factor for HR-HPV clearance.
Vaginal microecologyHigh-risk human papillomavirusClearance rateCervical cancer
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