Role of gut microbiome in alcohol-associated liver disease based on molecular mechanisms and biomarkers
Alcohol-associated liver disease includes a range of liver diseases,from steatosis to alcohol-related hepatitis,cirrhosis and hepatocellular carcinoma.At present,the underlying mechanisms involved in the pathophysiology of alcohol-associated liver disease remain unclear.In addition,bacteria,fungi,and viruses in the gut microbiome play an important role in the development of alcohol-associated liver disease,in which alcohol alters the function of the gut microbiome,leading to liver diseases.Given the significant correlation between gut microbiome,alcohol and liver injury,gut microbio-me has emerged as a potential biomarker and therapeutic target for alcohol-associated liver disease.This review focuses on exploring the potential mechanisms by which gut microbiome may be involved in the pathogenesis of alcohol-associated liver disease,and analyzes the potential of gut microbiome as a biomarker for monitoring and prognosis,so as to provide some references for the treatment of alcohol-associated liver disease.
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